prikaz prve stranice dokumenta Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection
  Download
PDF 868.6 KB
Scientific paper - Original scientific paper
Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection
Journal of General Virology, 74 (1993), 10; 2215-2223. https://doi.org/10.1099/0022-1317-74-10-2215
Pavić, Ivica; Polić, Bojan; Crnković, Irena; Lučin, Pero; Jonjić, Stipan; Koszinowski, U. H.

Cite this document

Pavić, I., Polić, B., Crnković, I., Lučin, P., Jonjić, S. & Koszinowski, U. H. (1993). Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection. Journal of General Virology, 74. (10), 2215-2223. doi: 10.1099/0022-1317-74-10-2215

Pavić, Ivica, et al. "Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection." Journal of General Virology, vol. 74, no. 10, 1993, pp. 2215-2223. https://doi.org/10.1099/0022-1317-74-10-2215

Pavić, Ivica, Bojan Polić, Irena Crnković, Pero Lučin, Stipan Jonjić and U. H. Koszinowski. "Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection." Journal of General Virology 74, no. 10 (1993): 2215-2223. https://doi.org/10.1099/0022-1317-74-10-2215

Pavić, I., et al. (1993) 'Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection', Journal of General Virology, 74(10), pp. 2215-2223. doi: 10.1099/0022-1317-74-10-2215

Pavić I, Polić B, Crnković I, Lučin P, Jonjić S, Koszinowski UH. Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection. Journal of General Virology [Internet]. 1993 October 01 [cited 2024 December 11];74(10):2215-2223. doi: 10.1099/0022-1317-74-10-2215

I. Pavić, B. Polić, I. Crnković, P. Lučin, S. Jonjić and U. H. Koszinowski, "Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection", Journal of General Virology, vol. 74, no. 10, pp. 2215-2223, October 1993. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:611848. [Accessed: 11 December 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection
AuthorIvica Pavić
AuthorBojan Polić
AuthorIrena Crnković
AuthorPero Lučin
AuthorStipan Jonjić
AuthorU. H. Koszinowski
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Interferon gamma (IFN gamma) represents an essential cytokine involved in murine cytomegalovirus (MCMV) clearance from the salivary gland and the control of horizontal transmission. Because IFN gamma cannot be responsible for all cytokine effects during recovery from MCMV infection we have now tested the potential participation of tumour necrosis factor alpha (TNF alpha) in the antiviral defence. Neutralization of endogenous TNF alpha abolished the antiviral activity of CD4 T cells in immunocompetent as well as in CD8 subset-deficient mice. These data suggest that the antiviral effect of the CD4 subset requires the presence of at least two cytokines, namely IFN gamma and TNF alpha. Depletion of endogenous TNF alpha in adoptive cell transfer recipients diminished the antiviral function of CD8 T lymphocytes suggesting that TNF alpha also participates in CD8 T cell effector functions. Furthermore, endogenous cytokines were found to be required for survival after infection with lethal doses of MCMV, whereas immunotherapy with recombinant TNF alpha and IFN gamma could not limit virus replication in vivo. The results suggest that, similar to IFN gamma, TNF alpha is an integral part of the protective mechanisms involved in cytomegalovirus clearance.
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of General Virology
Numberingvol. 74, no. 10, pp. 2215-2223
p-ISSN0022-1317
e-ISSN1465-2099
DOIhttps://doi.org/10.1099/0022-1317-74-10-2215
URN:NBNurn:nbn:hr:184:611848
Publication1993-10-01
Document URLhttp://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-74-10-2215
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-29 22:10:14