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ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS
Journal of Experimental Medicine, 179 (1994), 5; 1713-1717. https://doi.org/10.1084/jem.179.5.1713
Jonjić, Stipan; Pavić, Ivica; Polić, Bojan; Crnković, Irena; Koszinovski, UH

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Jonjić, S., Pavić, I., Polić, B., Crnković, I. i Koszinovski, U. (1994). ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS. Journal of Experimental Medicine, 179. (5), 1713-1717. doi: 10.1084/jem.179.5.1713

Jonjić, Stipan, et al. "ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS." Journal of Experimental Medicine, vol. 179, br. 5, 1994, str. 1713-1717. https://doi.org/10.1084/jem.179.5.1713

Jonjić, Stipan, Ivica Pavić, Bojan Polić, Irena Crnković i UH Koszinovski. "ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS." Journal of Experimental Medicine 179, br. 5 (1994): 1713-1717. https://doi.org/10.1084/jem.179.5.1713

Jonjić, S., et al. (1994) 'ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS', Journal of Experimental Medicine, 179(5), str. 1713-1717. doi: 10.1084/jem.179.5.1713

Jonjić S, Pavić I, Polić B, Crnković I, Koszinovski U. ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS. Journal of Experimental Medicine [Internet]. 05.1994. [pristupljeno 24.12.2024.];179(5):1713-1717. doi: 10.1084/jem.179.5.1713

S. Jonjić, I. Pavić, B. Polić, I. Crnković i U. Koszinovski, "ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS", Journal of Experimental Medicine, vol. 179, br. 5, str. 1713-1717, Svibanj 1994. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:502050. [Citirano: 24.12.2024.]

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Naslov (engleski)ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS
AutorStipan Jonjić
AutorIvica Pavić
AutorBojan Polić
AutorIrena Crnković
AutorUH Koszinovski
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Virus shedding from the epithelial cells of the serous acini of salivary glands is a major source for the horizontal transmission of cytomegalovirus. These cells are, different to other tissues, exempt from CD8 T lymphocyte control. CD4 T lymphocytes are essential to terminate the productive infection. Here, we prove that T-B cooperation and the production of antibodies are not required for this process. For the infection with murine cytomegalovirus, mutant mice were used which do not produce antibodies because of a disrupted membrane exon of the immunoglobulin mu chain gene. Also, in these mice the virus clearance from salivary glands is a function of CD4 T lymphocytes. However, these mice clear the virus and establish viral latency with a kinetics that is distinguishable from normal mice. Reactivation from virus latency is the only stage at which the absence of antibodies alters the phenotype of infection. In immunoglobulin-deficient mice, virus recurrence results in higher virus titers. The adoptive serum transfer proved that antibody is the limited factor that prevents virus dissemination in the immunodeficient host.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pismo
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Experimental Medicine
Brojčani podacivol. 179, br. 5, str. 1713-1717
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.179.5.1713
URN:NBNurn:nbn:hr:184:502050
Datum objave publikacije1994-05
URL dokumentahttp://jem.rupress.org/content/jem/179/5/1713.full.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2017-12-28 10:22:13