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Scientific paper - Letter
ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS
Journal of Experimental Medicine, 179 (1994), 5; 1713-1717. https://doi.org/10.1084/jem.179.5.1713
Jonjić, Stipan; Pavić, Ivica; Polić, Bojan; Crnković, Irena; Koszinovski, UH

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Jonjić, S., Pavić, I., Polić, B., Crnković, I. & Koszinovski, U. (1994). ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS. Journal of Experimental Medicine, 179. (5), 1713-1717. doi: 10.1084/jem.179.5.1713

Jonjić, Stipan, et al. "ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS." Journal of Experimental Medicine, vol. 179, no. 5, 1994, pp. 1713-1717. https://doi.org/10.1084/jem.179.5.1713

Jonjić, Stipan, Ivica Pavić, Bojan Polić, Irena Crnković and UH Koszinovski. "ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS." Journal of Experimental Medicine 179, no. 5 (1994): 1713-1717. https://doi.org/10.1084/jem.179.5.1713

Jonjić, S., et al. (1994) 'ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS', Journal of Experimental Medicine, 179(5), pp. 1713-1717. doi: 10.1084/jem.179.5.1713

Jonjić S, Pavić I, Polić B, Crnković I, Koszinovski U. ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS. Journal of Experimental Medicine [Internet]. 1994 May [cited 2024 December 25];179(5):1713-1717. doi: 10.1084/jem.179.5.1713

S. Jonjić, I. Pavić, B. Polić, I. Crnković and U. Koszinovski, "ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS", Journal of Experimental Medicine, vol. 179, no. 5, pp. 1713-1717, May 1994. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:502050. [Accessed: 25 December 2024]

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Metadata
Title (english)ANTIBODIES ARE NOT ESSENTIAL FOR THE RESOLUTION OF PRIMARY CYTOMEGALOVIRUS-INFECTION BUT LIMIT DISSEMINATION OF RECURRENT VIRUS
AuthorStipan Jonjić
AuthorIvica Pavić
AuthorBojan Polić
AuthorIrena Crnković
AuthorUH Koszinovski
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Virus shedding from the epithelial cells of the serous acini of salivary glands is a major source for the horizontal transmission of cytomegalovirus. These cells are, different to other tissues, exempt from CD8 T lymphocyte control. CD4 T lymphocytes are essential to terminate the productive infection. Here, we prove that T-B cooperation and the production of antibodies are not required for this process. For the infection with murine cytomegalovirus, mutant mice were used which do not produce antibodies because of a disrupted membrane exon of the immunoglobulin mu chain gene. Also, in these mice the virus clearance from salivary glands is a function of CD4 T lymphocytes. However, these mice clear the virus and establish viral latency with a kinetics that is distinguishable from normal mice. Reactivation from virus latency is the only stage at which the absence of antibodies alters the phenotype of infection. In immunoglobulin-deficient mice, virus recurrence results in higher virus titers. The adoptive serum transfer proved that antibody is the limited factor that prevents virus dissemination in the immunodeficient host.
Keywords (english)
Languageenglish
Publication typeScientific paper - Letter
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Experimental Medicine
Numberingvol. 179, no. 5, pp. 1713-1717
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.179.5.1713
URN:NBNurn:nbn:hr:184:502050
Publication1994-05
Document URLhttp://jem.rupress.org/content/jem/179/5/1713.full.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2017-12-28 10:22:13