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Humani papiloma virus i karcinom cerviksa: mehanizmi karcinogeneze, epidemiologija, dijagnostika i profilaksa
Medicina Fluminensis : Medicina Fluminensis, 46 (2010), 2; 112-123. urn:nbn:hr:184:629959
Hadžisejdić, Ita; Grce, Magdalena; Grahovac, Blaženka

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Hadžisejdić, I., Grce, M. & Grahovac, B. (2010). Humani papiloma virus i karcinom cerviksa: mehanizmi karcinogeneze, epidemiologija, dijagnostika i profilaksa. Medicina Fluminensis : Medicina Fluminensis, 46. (2), 112-123. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:629959

Hadžisejdić, Ita, et al. "Humani papiloma virus i karcinom cerviksa: mehanizmi karcinogeneze, epidemiologija, dijagnostika i profilaksa." Medicina Fluminensis : Medicina Fluminensis, vol. 46, no. 2, 2010, pp. 112-123. https://urn.nsk.hr/urn:nbn:hr:184:629959

Hadžisejdić, Ita, Magdalena Grce and Blaženka Grahovac. "Humani papiloma virus i karcinom cerviksa: mehanizmi karcinogeneze, epidemiologija, dijagnostika i profilaksa." Medicina Fluminensis : Medicina Fluminensis 46, no. 2 (2010): 112-123. https://urn.nsk.hr/urn:nbn:hr:184:629959

Hadžisejdić, I., Grce, M. and Grahovac, B. (2010) 'Humani papiloma virus i karcinom cerviksa: mehanizmi karcinogeneze, epidemiologija, dijagnostika i profilaksa', Medicina Fluminensis : Medicina Fluminensis, 46(2), pp. 112-123. Available at: https://urn.nsk.hr/urn:nbn:hr:184:629959 (Accessed 06 May 2024)

Hadžisejdić I, Grce M, Grahovac B. Humani papiloma virus i karcinom cerviksa: mehanizmi karcinogeneze, epidemiologija, dijagnostika i profilaksa. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2010 June 07 [cited 2024 May 06];46(2):112-123. Available at: https://urn.nsk.hr/urn:nbn:hr:184:629959

I. Hadžisejdić, M. Grce and B. Grahovac, "Humani papiloma virus i karcinom cerviksa: mehanizmi karcinogeneze, epidemiologija, dijagnostika i profilaksa", Medicina Fluminensis : Medicina Fluminensis, vol. 46, no. 2, pp. 112-123, June 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:629959. [Accessed: 06 May 2024]

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Metadata
Title (croatian)Humani papiloma virus i karcinom cerviksa: mehanizmi karcinogeneze, epidemiologija, dijagnostika i profilaksa
Title (english)Human papillomavirus and cervical cancer: mechanisms of carcinogenesis, epidemiology, diagnostics and prophylaxis
AuthorIta Hadžisejdić
AuthorMagdalena Grce
AuthorBlaženka Grahovac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (croatian)
Infekcija humanim papiloma virusom (HPV) najčešća je spolno prenosiva bolest i pretpostavlja se da genitalnu infekciju ovim virusom ti jekom života stekne 75 – 80 % spolno aktivnih žena i muškaraca. Od ranih osamdeseti h kada je Harald zur Hausen (dobitnik Nobelove nagrade za fiziologiju ili medicinu 2008. godine) dokazao humani papiloma virus (HPV) genotipa 16 i 18 u karcinomu cerviksa, u velikom broju studija potvrđeno je i znanstvenim činjenicama dokazano da je infekcija HPV-om ključni čimbenik u razvoju karcinoma cerviksa. Maligne promjene cerviksa nastaju ako su ispunjeni višestruki uvjeti koji su defi nirani virusnim značajkama, staničnim protuvirusnim mehanizmima i imunim odgovorom domaćina. Virusnu komponentu čine genoti p virusa, perzistencija i intenzitet infekcije, a imunogenetička konstitucija pojedinca, stanično posredovani imuni odgovor i utjecaj vanjskih čimbenika kao što su lijekovi i bolesti, definiraju imunopatogenetski doprinos domaćina. Ključni proteini uključeni u nastanak karcinoma cerviksa su virusni onkogeni, E6 i E7, koji interferiraju s nizom staničnih procesa te dovode do nekontrolirane proliferacije i stanične imortalizacije, stoga je značaj molekularnih studija koje se bave problematikom HPV-a upravo u boljem razumijevanju patogeneze HPV-a te primjeni stečenih spoznaja u prevenciji virusne infekcije, razvoju profilaktičkog cjepiva i uvođenju molekularne dijagnosti ke kao standarda u procjeni rizika za žene izložene kroničnoj infekciji HPV-om.
Abstract (english)
Human papillomavirus (HPV) infecti on is esti mated to be the most common sexually transmitt ed disease and about 75-80% of sexually active men and women will be infected with HPV at some point in their lifeti me. Since the early 1980s when Harald zur Hausen (winner of the Nobel Prize in 2008 for Physiology or Medicine) detected the HPV genotypes 16 and 18 in cervical cancer, a large number of studies have provided scienti fi c evidence that HPV infection is a key factor in the development of cervical carcinoma. Malignant changes of the cervix occur if multiple conditions are met and they are defined by virus characteristics, anti viral mechanisms and by the cellular immune response of the host. Viral components important in carcinogenesis are viral genotype, intensity and persistence of the infecti on, while immunogenetic constitution of the individual, cell mediated immune responses and influence of the external factors such as drugs and diseases defi ne immunopathogenetic contributi on of the host. Key proteins involved in the development of cervical cancer are viral oncogenes, E6 and E7, which interfere with a variety of cellular processes and lead to uncontrolled cell proliferati on and immortalisation. Therefore, the importance of molecular studies dealing with HPV lies in the fact that they enable us to better understand the HPV pathogenesis and facilitate application of the acquired knowledge in the preventi on of HPV infections, development of prophylactic vaccines and introducti on of molecular diagnosti cs as a standard in the risk assessment for women exposed to the chronic HPV infection.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 46, no. 2, pp. 112-123
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:629959
Publication2010-06-07
Document URLhttp://hrcak.srce.hr/53154
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-08 13:15:01