prikaz prve stranice dokumenta Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis
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Scientific paper - Original scientific paper
Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis
Immunity, 58 (2025), 1; 124-142.. https://doi.org/10.1016/j.immuni.2024.11.023
Diehl, Carina; Soberón, Valeria; Baygün, Seren; Chu, Yuanyuan; Mandelbaum, Jonathan; Kraus, Laura; Engleitner, Thomas; Rudelius, Martina; Fangazio, Marco; Daniel, Christoph; Bortoluzzi, Sabrina; Helmrath, Sabine; Singroul, Pankaj; Gölling, Vanessa; Osorio Barrios, Francisco; Seyhan, Gönül; Oßwald, Lena; Kober-Hasslacher, Maike; Zeng, Theodor; Öllinger, Rupert; Afzali, Ali M.; Korn, Thomas; Honarpisheh, Mohsen; Lech, Maciej; Ul Ain, Qurrat; Pircher, Joachim; Imširović, Vanna; Jelenčić, Vedrana; Wensveen, Felix M.; Passerini, Verena; Bärthel, Stefanie; Bhagat, Govind; Dominguez-Sola, David; Saur, Dieter; Steiger, Katja; Rad, Roland; Pasqualucci, Laura; Weigert, Oliver; Schmidt-Supprian, Marc More authors...

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Diehl, C., Soberón, V., Baygün, S., Chu, Y., Mandelbaum, J., Kraus, L. ... Schmidt Supprian, M. (2025). Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis. Immunity, 58. (1), 124-142.. doi: 10.1016/j.immuni.2024.11.023

Diehl, Carina, et al. "Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis." Immunity, vol. 58, no. 1, 2025, pp. 124-142.. https://doi.org/10.1016/j.immuni.2024.11.023

Diehl, Carina, Valeria Soberón, Seren Baygün, Yuanyuan Chu, Jonathan Mandelbaum, Laura Kraus, Thomas Engleitner, et al. "Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis." Immunity 58, no. 1 (2025): 124-142.. https://doi.org/10.1016/j.immuni.2024.11.023

Diehl, C., et al. (2025) 'Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis', Immunity, 58(1), pp. 124-142.. doi: 10.1016/j.immuni.2024.11.023

Diehl C, Soberón V, Baygün S, Chu Y, Mandelbaum J, Kraus L, and sur.. Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis. Immunity [Internet]. 2025 January [cited 2025 February 03];58(1):124-142.. doi: 10.1016/j.immuni.2024.11.023

C. Diehl, et al., "Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis", Immunity, vol. 58, no. 1, pp. 124-142., January 2025. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:719667. [Accessed: 03 February 2025]

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Metadata
Title (english)Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis
AuthorCarina Diehl
AuthorValeria Soberón
AuthorSeren Baygün
AuthorYuanyuan Chu
AuthorJonathan Mandelbaum
AuthorLaura Kraus
AuthorThomas Engleitner
AuthorMartina Rudelius
AuthorMarco Fangazio
AuthorChristoph Daniel
AuthorSabrina Bortoluzzi
AuthorSabine Helmrath
AuthorPankaj Singroul
AuthorVanessa Gölling
AuthorFrancisco Osorio Barrios
AuthorGönül Seyhan
AuthorLena Oßwald
AuthorMaike Kober-Hasslacher
AuthorTheodor Zeng
AuthorRupert Öllinger
AuthorAli M. Afzali
AuthorThomas Korn
AuthorMohsen Honarpisheh
AuthorMaciej Lech
AuthorQurrat Ul Ain
AuthorJoachim Pircher
AuthorVanna Imširović
AuthorVedrana Jelenčić
AuthorFelix M. Wensveen
AuthorVerena Passerini
AuthorStefanie Bärthel
AuthorGovind Bhagat
AuthorDavid Dominguez-Sola
AuthorDieter Saur
AuthorKatja Steiger
AuthorRoland Rad
AuthorLaura Pasqualucci
AuthorOliver Weigert
AuthorMarc Schmidt-Supprian
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
B cell immunity carries the inherent risk of deviating into autoimmunity and malignancy, which are both strongly associated with genetic variants or alterations that increase immune signaling. Here, we investigated the interplay of autoimmunity and lymphoma risk factors centered around the archetypal negative immune regulator TNFAIP3/A20 in mice. Counterintuitively, B cells with moderately elevated sensitivity to stimulation caused fatal autoimmune pathology, while those with high sensitivity did not. We resolved this apparent paradox by identifying a rheostat-like cytotoxic T cell checkpoint. Cytotoxicity was instructed by and directed against B cells with high intrinsic hyperresponsiveness, while less reactive cells were spared. Removing T cell control restored a linear relationship between intrinsic B cell reactivity and lethal lymphoproliferation, lymphomagenesis, and autoinflammation. We thus identify powerful T cell-mediated negative feedback control of inherited and acquired B cell pathogenicity and define a permissive window for autoimmunity to emerge.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleImmunity
Numberingvol. 58, no. 1, pp. 124-142., e15
p-ISSN1074-7613
DOIhttps://doi.org/10.1016/j.immuni.2024.11.023
URN:NBNurn:nbn:hr:184:719667
Publication2025-01
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S1074761324005387
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-01-21 13:08:30