prikaz prve stranice dokumenta Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis
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Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis
Immunity, 58 (2025), 1; 124-142.. https://doi.org/10.1016/j.immuni.2024.11.023
Diehl, Carina; Soberón, Valeria; Baygün, Seren; Chu, Yuanyuan; Mandelbaum, Jonathan; Kraus, Laura; Engleitner, Thomas; Rudelius, Martina; Fangazio, Marco; Daniel, Christoph; Bortoluzzi, Sabrina; Helmrath, Sabine; Singroul, Pankaj; Gölling, Vanessa; Osorio Barrios, Francisco; Seyhan, Gönül; Oßwald, Lena; Kober-Hasslacher, Maike; Zeng, Theodor; Öllinger, Rupert; Afzali, Ali M.; Korn, Thomas; Honarpisheh, Mohsen; Lech, Maciej; Ul Ain, Qurrat; Pircher, Joachim; Imširović, Vanna; Jelenčić, Vedrana; Wensveen, Felix M.; Passerini, Verena; Bärthel, Stefanie; Bhagat, Govind; Dominguez-Sola, David; Saur, Dieter; Steiger, Katja; Rad, Roland; Pasqualucci, Laura; Weigert, Oliver; Schmidt-Supprian, Marc Više autora...

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Diehl, C., Soberón, V., Baygün, S., Chu, Y., Mandelbaum, J., Kraus, L. ... Schmidt Supprian, M. (2025). Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis. Immunity, 58. (1), 124-142.. doi: 10.1016/j.immuni.2024.11.023

Diehl, Carina, et al. "Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis." Immunity, vol. 58, br. 1, 2025, str. 124-142.. https://doi.org/10.1016/j.immuni.2024.11.023

Diehl, Carina, Valeria Soberón, Seren Baygün, Yuanyuan Chu, Jonathan Mandelbaum, Laura Kraus, Thomas Engleitner, et al. "Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis." Immunity 58, br. 1 (2025): 124-142.. https://doi.org/10.1016/j.immuni.2024.11.023

Diehl, C., et al. (2025) 'Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis', Immunity, 58(1), str. 124-142.. doi: 10.1016/j.immuni.2024.11.023

Diehl C, Soberón V, Baygün S, Chu Y, Mandelbaum J, Kraus L, i sur.. Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis. Immunity [Internet]. 01.2025. [pristupljeno 05.02.2025.];58(1):124-142.. doi: 10.1016/j.immuni.2024.11.023

C. Diehl, et al., "Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis", Immunity, vol. 58, br. 1, str. 124-142., Siječanj 2025. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:719667. [Citirano: 05.02.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:719667
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Naslov (engleski)Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis
AutorCarina Diehl
AutorValeria Soberón
AutorSeren Baygün
AutorYuanyuan Chu
AutorJonathan Mandelbaum
AutorLaura Kraus
AutorThomas Engleitner
AutorMartina Rudelius
AutorMarco Fangazio
AutorChristoph Daniel
AutorSabrina Bortoluzzi
AutorSabine Helmrath
AutorPankaj Singroul
AutorVanessa Gölling
AutorFrancisco Osorio Barrios
AutorGönül Seyhan
AutorLena Oßwald
AutorMaike Kober-Hasslacher
AutorTheodor Zeng
AutorRupert Öllinger
AutorAli M. Afzali
AutorThomas Korn
AutorMohsen Honarpisheh
AutorMaciej Lech
AutorQurrat Ul Ain
AutorJoachim Pircher
AutorVanna Imširović
AutorVedrana Jelenčić
AutorFelix M. Wensveen
AutorVerena Passerini
AutorStefanie Bärthel
AutorGovind Bhagat
AutorDavid Dominguez-Sola
AutorDieter Saur
AutorKatja Steiger
AutorRoland Rad
AutorLaura Pasqualucci
AutorOliver Weigert
AutorMarc Schmidt-Supprian
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
B cell immunity carries the inherent risk of deviating into autoimmunity and malignancy, which are both strongly associated with genetic variants or alterations that increase immune signaling. Here, we investigated the interplay of autoimmunity and lymphoma risk factors centered around the archetypal negative immune regulator TNFAIP3/A20 in mice. Counterintuitively, B cells with moderately elevated sensitivity to stimulation caused fatal autoimmune pathology, while those with high sensitivity did not. We resolved this apparent paradox by identifying a rheostat-like cytotoxic T cell checkpoint. Cytotoxicity was instructed by and directed against B cells with high intrinsic hyperresponsiveness, while less reactive cells were spared. Removing T cell control restored a linear relationship between intrinsic B cell reactivity and lethal lymphoproliferation, lymphomagenesis, and autoinflammation. We thus identify powerful T cell-mediated negative feedback control of inherited and acquired B cell pathogenicity and define a permissive window for autoimmunity to emerge.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaImmunity
Brojčani podacivol. 58, br. 1, str. 124-142., e15
p-ISSN1074-7613
DOIhttps://doi.org/10.1016/j.immuni.2024.11.023
URN:NBNurn:nbn:hr:184:719667
Datum objave publikacije2025-01
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S1074761324005387
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-01-21 13:08:30