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Scientific paper - Review paper
Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery
Current Issues in Molecular Biology, 46 (2024), 5; 3794-3809. https://doi.org/10.3390/cimb46050236
Kršek, Antea; Batičić, Lara; Ćurko-Cofek, Božena; Batinac, Tanja; Laškarin, Gordana; Miletić-Gršković, Silvija; Sotošek, Vlatka

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Kršek, A., Batičić, L., Ćurko Cofek, B., Batinac, T., Laškarin, G., Miletić Gršković, S. & Sotošek, V. (2024). Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery. Current Issues in Molecular Biology, 46. (5), 3794-3809. doi: 10.3390/cimb46050236

Kršek, Antea, et al. "Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery." Current Issues in Molecular Biology, vol. 46, no. 5, 2024, pp. 3794-3809. https://doi.org/10.3390/cimb46050236

Kršek, Antea, Lara Batičić, Božena Ćurko Cofek, Tanja Batinac, Gordana Laškarin, Silvija Miletić Gršković and Vlatka Sotošek. "Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery." Current Issues in Molecular Biology 46, no. 5 (2024): 3794-3809. https://doi.org/10.3390/cimb46050236

Kršek, A., et al. (2024) 'Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery', Current Issues in Molecular Biology, 46(5), pp. 3794-3809. doi: 10.3390/cimb46050236

Kršek A, Batičić L, Ćurko Cofek B, Batinac T, Laškarin G, Miletić Gršković S, and sur.. Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery. Current Issues in Molecular Biology [Internet]. 2024 April 23 [cited 2024 December 26];46(5):3794-3809. doi: 10.3390/cimb46050236

A. Kršek, et al., "Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery", Current Issues in Molecular Biology, vol. 46, no. 5, pp. 3794-3809, April 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:401276. [Accessed: 26 December 2024]

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Metadata
Title (english)Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery
AuthorAntea Kršek
AuthorLara Batičić
AuthorBožena Ćurko-Cofek
AuthorTanja Batinac
AuthorGordana Laškarin
AuthorSilvija Miletić-Gršković
AuthorVlatka Sotošek
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The endothelial glycocalyx (EGC) is a layer of proteoglycans (associated with glycosaminoglycans) and glycoproteins, which adsorbs plasma proteins on the luminal surface of endothelial cells. Its main function is to participate in separating the circulating blood from the inner layers of the vessels and the surrounding tissues. Physiologically, the EGC stimulates mechanotransduction, the endothelial charge, thrombocyte adhesion, leukocyte tissue recruitment, and molecule extravasation. Hence, severe impairment of the EGC has been implicated in various pathological conditions, including sepsis, diabetes, chronic kidney disease, inflammatory disorders, hypernatremia, hypervolemia, atherosclerosis, and ischemia/reperfusion injury. Moreover, alterations in EGC have been associated with altered responses to therapeutic interventions in conditions such as cardiovascular diseases. Investigation into the function of the glycocalyx has expanded knowledge about vascular disorders and indicated the need to consider new approaches in the treatment of severe endothelial dysfunction. This review aims to present the current understanding of the molecular mechanisms underlying cardiovascular diseases and to elucidate the impact of heart surgery on EGC dysfunction.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCurrent Issues in Molecular Biology
Numberingvol. 46, no. 5, pp. 3794-3809
e-ISSN1467-3045
DOIhttps://doi.org/10.3390/cimb46050236
URN:NBNurn:nbn:hr:184:401276
Publication2024-04-23
ProjectNumber: IPS-2023-02-9650
Title (english): Endothelial dysfunction, inflammation and oxidative stress in patients undergoing cardiac surgery—EDIOS
Acronym: EDIOS
Leader: Vlatka Sotošek Tokmadžić
Jurisdiction: Croatia
Funding stream: Research Projects
Document URLhttps://www.mdpi.com/1467-3045/46/5/236
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-04-24 08:21:32