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Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery
Current Issues in Molecular Biology, 46 (2024), 5; 3794-3809. https://doi.org/10.3390/cimb46050236
Kršek, Antea; Batičić, Lara; Ćurko-Cofek, Božena; Batinac, Tanja; Laškarin, Gordana; Miletić-Gršković, Silvija; Sotošek, Vlatka

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Kršek, A., Batičić, L., Ćurko Cofek, B., Batinac, T., Laškarin, G., Miletić Gršković, S. i Sotošek, V. (2024). Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery. Current Issues in Molecular Biology, 46. (5), 3794-3809. doi: 10.3390/cimb46050236

Kršek, Antea, et al. "Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery." Current Issues in Molecular Biology, vol. 46, br. 5, 2024, str. 3794-3809. https://doi.org/10.3390/cimb46050236

Kršek, Antea, Lara Batičić, Božena Ćurko Cofek, Tanja Batinac, Gordana Laškarin, Silvija Miletić Gršković i Vlatka Sotošek. "Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery." Current Issues in Molecular Biology 46, br. 5 (2024): 3794-3809. https://doi.org/10.3390/cimb46050236

Kršek, A., et al. (2024) 'Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery', Current Issues in Molecular Biology, 46(5), str. 3794-3809. doi: 10.3390/cimb46050236

Kršek A, Batičić L, Ćurko Cofek B, Batinac T, Laškarin G, Miletić Gršković S, i sur.. Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery. Current Issues in Molecular Biology [Internet]. 23.04.2024. [pristupljeno 15.11.2024.];46(5):3794-3809. doi: 10.3390/cimb46050236

A. Kršek, et al., "Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery", Current Issues in Molecular Biology, vol. 46, br. 5, str. 3794-3809, Travanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:401276. [Citirano: 15.11.2024.]

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Podaci o radu
Naslov (engleski)Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery
AutorAntea Kršek
AutorLara Batičić
AutorBožena Ćurko-Cofek
AutorTanja Batinac
AutorGordana Laškarin
AutorSilvija Miletić-Gršković
AutorVlatka Sotošek
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za dermatovenerologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The endothelial glycocalyx (EGC) is a layer of proteoglycans (associated with glycosaminoglycans) and glycoproteins, which adsorbs plasma proteins on the luminal surface of endothelial cells. Its main function is to participate in separating the circulating blood from the inner layers of the vessels and the surrounding tissues. Physiologically, the EGC stimulates mechanotransduction, the endothelial charge, thrombocyte adhesion, leukocyte tissue recruitment, and molecule extravasation. Hence, severe impairment of the EGC has been implicated in various pathological conditions, including sepsis, diabetes, chronic kidney disease, inflammatory disorders, hypernatremia, hypervolemia, atherosclerosis, and ischemia/reperfusion injury. Moreover, alterations in EGC have been associated with altered responses to therapeutic interventions in conditions such as cardiovascular diseases. Investigation into the function of the glycocalyx has expanded knowledge about vascular disorders and indicated the need to consider new approaches in the treatment of severe endothelial dysfunction. This review aims to present the current understanding of the molecular mechanisms underlying cardiovascular diseases and to elucidate the impact of heart surgery on EGC dysfunction.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCurrent Issues in Molecular Biology
Brojčani podacivol. 46, br. 5, str. 3794-3809
e-ISSN1467-3045
DOIhttps://doi.org/10.3390/cimb46050236
URN:NBNurn:nbn:hr:184:401276
Datum objave publikacije2024-04-23
ProjektŠifra: IPS-2023-02-9650
Naziv (engleski): Endothelial dysfunction, inflammation and oxidative stress in patients undergoing cardiac surgery—EDIOS
Kratica: EDIOS
Voditelj: Vlatka Sotošek Tokmadžić
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
URL dokumentahttps://www.mdpi.com/1467-3045/46/5/236
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-04-24 08:21:32