prikaz prve stranice dokumenta Secondary polycythemia in acutely ill COVID-19 patients is associated with higher mortality but not markedly higher thrombotic risk
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Scientific paper - Original scientific paper
Secondary polycythemia in acutely ill COVID-19 patients is associated with higher mortality but not markedly higher thrombotic risk
Scandinavian Journal of Clinical and Laboratory Investigation, 27 (2024); 1-7. https://doi.org/10.1080/00365513.2024.2321589
Lucijanić, Marko; Krečak, Ivan; Sorić, Ena; Sabljić, Anica; Vasilj, Tamara; Cicic, David; Vrkljan Vuk, Anamarija; Kremer, Zvonimir; Dilber, Ivo; Glasnović, Anton; Jakšić, Ozren; Kušec, Rajko

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Lucijanić, M., Krečak, I., Sorić, E., Sabljić, A., Vasilj, T., Cicic, D. ... Kušec, R. (2024). Secondary polycythemia in acutely ill COVID-19 patients is associated with higher mortality but not markedly higher thrombotic risk. Scandinavian Journal of Clinical and Laboratory Investigation, 27., 1-7. doi: 10.1080/00365513.2024.2321589

Lucijanić, Marko, et al. "Secondary polycythemia in acutely ill COVID-19 patients is associated with higher mortality but not markedly higher thrombotic risk." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 27, 2024, pp. 1-7. https://doi.org/10.1080/00365513.2024.2321589

Lucijanić, Marko, Ivan Krečak, Ena Sorić, Anica Sabljić, Tamara Vasilj, David Cicic, Anamarija Vrkljan Vuk, et al. "Secondary polycythemia in acutely ill COVID-19 patients is associated with higher mortality but not markedly higher thrombotic risk." Scandinavian Journal of Clinical and Laboratory Investigation 27 (2024): 1-7. https://doi.org/10.1080/00365513.2024.2321589

Lucijanić, M., et al. (2024) 'Secondary polycythemia in acutely ill COVID-19 patients is associated with higher mortality but not markedly higher thrombotic risk', Scandinavian Journal of Clinical and Laboratory Investigation, 27, pp. 1-7. doi: 10.1080/00365513.2024.2321589

Lucijanić M, Krečak I, Sorić E, Sabljić A, Vasilj T, Cicic D, and sur.. Secondary polycythemia in acutely ill COVID-19 patients is associated with higher mortality but not markedly higher thrombotic risk. Scandinavian Journal of Clinical and Laboratory Investigation [Internet]. 2024 February 27 [cited 2024 December 03];27:1-7. doi: 10.1080/00365513.2024.2321589

M. Lucijanić, et al., "Secondary polycythemia in acutely ill COVID-19 patients is associated with higher mortality but not markedly higher thrombotic risk", Scandinavian Journal of Clinical and Laboratory Investigation, vol. 27, pp. 1-7, February 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:905823. [Accessed: 03 December 2024]

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Metadata
Title (english)Secondary polycythemia in acutely ill COVID-19 patients is associated with higher mortality but not markedly higher thrombotic risk
AuthorMarko Lucijanić
AuthorIvan Krečak
AuthorEna Sorić
AuthorAnica Sabljić
AuthorTamara Vasilj
AuthorDavid Cicic
AuthorAnamarija Vrkljan Vuk
AuthorZvonimir Kremer
AuthorIvo Dilber
AuthorAnton Glasnović
AuthorOzren Jakšić
AuthorRajko Kušec
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Secondary polycythemia is commonly observed among patients with chronic pulmonary diseases. However, its significance in the context of Coronavirus disease 2019 (COVID-19) is unknown. We retrospectively evaluated a total of 5872 hospitalized COVID-19 patients with mostly severe and critical symptoms, and without prior or subsequently diagnosed myeloproliferative neoplasm. Patients were stratified based on admission hemoglobin into four subgroups: anemia (hemoglobin <120 g/L for females and 130 g/L for males), normal hemoglobin, mild (hemoglobin 160-165 g/L for females and 165-185 g/L for males) and severe polycythemia (hemoglobin >165 g/L for females and >185 g/L for males). Among 5872 patients, a total of 158 (2.7%) had mild and 25 (0.4%) severe polycythemia. Polycythemia was significantly associated with higher respiratory and functional impairment, reduced plasma volume, higher serum osmolarity and comorbidity burden specific to the degree of polycythemia. Patients presenting with mild (odds ratio (OR) = 1.63, p = .003) and severe polycythemia (OR = 4.98, p < .001) had increased risk of death in comparison to patients with normal hemoglobin, whereas no significant associations with venous thromboembolism, arterial thrombosis nor major bleeding were observed. Anemia was associated with higher risk of death (OR = 1.42, p < .001), venous thromboembolism (OR = 1.34, p < .006) and major bleeding (OR = 2.27, p < .001) in comparison to normal hemoglobin. Associations of polycythemia and anemia with mortality diminished, and anemia with venous thromboembolism and major bleeding persisted, after multivariate adjustments for age, sex, comorbidities, COVID-19 severity and functional status. Secondary polycythemia in hospitalized COVID-19 patients without prior of subsequently diagnosed myeloproliferative neoplasm is rare and is associated with high mortality, increasing with degree of polycythemia, but not markedly higher thrombotic risk
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleScandinavian Journal of Clinical and Laboratory Investigation
Numberingvol. 27, pp. 1-7, 2321589
p-ISSN0036-5513
e-ISSN1502-7686
DOIhttps://doi.org/10.1080/00365513.2024.2321589
URN:NBNurn:nbn:hr:184:905823
Publication2024-02-27
Document URLhttps://www.tandfonline.com/doi/full/10.1080/00365513.2024.2321589
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2024-04-08 11:47:21