prikaz prve stranice dokumenta The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors
No public access
Scientific paper - Original scientific paper
The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors
Pathology - Research and Practice, 244 (2023); 154416. https://doi.org/10.1016/j.prp.2023.154416
Dekanić, Andrea; Babarović, Emina; Kučan Brlić, Paola; Knežić, Matija; Savić Vuković, Anita; Mazor, Marija; Jonjić, Nives

Cite this document

Dekanić, A., Babarović, E., Kučan Brlić, P., Knežić, M., Savić Vuković, A., Mazor, M. & Jonjić, N. (2023). The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors. Pathology - Research and Practice, 244.. doi: 10.1016/j.prp.2023.154416

Dekanić, Andrea, et al. "The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors." Pathology - Research and Practice, vol. 244, 2023. https://doi.org/10.1016/j.prp.2023.154416

Dekanić, Andrea, Emina Babarović, Paola Kučan Brlić, Matija Knežić, Anita Savić Vuković, Marija Mazor and Nives Jonjić. "The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors." Pathology - Research and Practice 244 (2023). https://doi.org/10.1016/j.prp.2023.154416

Dekanić, A., et al. (2023) 'The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors', Pathology - Research and Practice, 244. doi: 10.1016/j.prp.2023.154416

Dekanić A, Babarović E, Kučan Brlić P, Knežić M, Savić Vuković A, Mazor M, and sur.. The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors. Pathology - Research and Practice [Internet]. 2023 April [cited 2024 November 19];244. doi: 10.1016/j.prp.2023.154416

A. Dekanić, et al., "The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors", Pathology - Research and Practice, vol. 244, April 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:054240. [Accessed: 19 November 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors
AuthorAndrea Dekanić
AuthorEmina Babarović
AuthorPaola Kučan Brlić
AuthorMatija Knežić
AuthorAnita Savić Vuković
AuthorMarija Mazor
AuthorNives Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
Glial tumors are the most frequent neoplasms of the central nervous system in adults and despite recent advances in diagnosis and treatment of the disease, the prognosis of glioma is poor. Therefore, there is a great need to identify new prognostic factors and potential immunotherapeutic targets. Members of the Nectin family of proteins are gaining significant attention as possible diagnostic and immunotherapeutic targets in many solid tumors, but they have not been extensively investigated in glial tumors. The aim of the present study was to evaluate the expression of Nectin-2 and Nectin-4 in glial tumors of different grades, and to assess their prognostic value. The results showed heterogeneous expression of Nectin-2 and Nectin-4 in tumor cells and neuropil, with significantly higher Nectin-2 expression compared to Nectin-4, but without differences among tumor grades. In addition, the expression of Nectin-2 and Nectin-4 was associated with shorter survival times in patients with grade II/III gliomas. These results suggest that Nectin-2 and Nectin-4 expression may be used as an independent prognostic indicator for patients with II/III gliomas. This study contributes to the development of personalized care for patients with glioma and provides a basis for further research on nectin-based immunotherapy for brain tumors.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePathology - Research and Practice
Numberingvol. 244, 154416
p-ISSN0344-0338
DOIhttps://doi.org/10.1016/j.prp.2023.154416
URN:NBNurn:nbn:hr:184:054240
Publication2023-04
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0344033823001164
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2023-08-23 07:41:37