prikaz prve stranice dokumenta The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors
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The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors
Pathology - Research and Practice, 244 (2023); 154416. https://doi.org/10.1016/j.prp.2023.154416
Dekanić, Andrea; Babarović, Emina; Kučan Brlić, Paola; Knežić, Matija; Savić Vuković, Anita; Mazor, Marija; Jonjić, Nives

Citirajte ovaj rad

Dekanić, A., Babarović, E., Kučan Brlić, P., Knežić, M., Savić Vuković, A., Mazor, M. i Jonjić, N. (2023). The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors. Pathology - Research and Practice, 244.. doi: 10.1016/j.prp.2023.154416

Dekanić, Andrea, et al. "The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors." Pathology - Research and Practice, vol. 244, 2023. https://doi.org/10.1016/j.prp.2023.154416

Dekanić, Andrea, Emina Babarović, Paola Kučan Brlić, Matija Knežić, Anita Savić Vuković, Marija Mazor i Nives Jonjić. "The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors." Pathology - Research and Practice 244 (2023). https://doi.org/10.1016/j.prp.2023.154416

Dekanić, A., et al. (2023) 'The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors', Pathology - Research and Practice, 244. doi: 10.1016/j.prp.2023.154416

Dekanić A, Babarović E, Kučan Brlić P, Knežić M, Savić Vuković A, Mazor M, i sur.. The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors. Pathology - Research and Practice [Internet]. 04.2023. [pristupljeno 14.11.2024.];244. doi: 10.1016/j.prp.2023.154416

A. Dekanić, et al., "The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors", Pathology - Research and Practice, vol. 244, Travanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:054240. [Citirano: 14.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:054240
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Podaci o radu
Naslov (engleski)The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors
AutorAndrea Dekanić
AutorEmina Babarović
AutorPaola Kučan Brlić
AutorMatija Knežić
AutorAnita Savić Vuković
AutorMarija Mazor
AutorNives Jonjić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Glial tumors are the most frequent neoplasms of the central nervous system in adults and despite recent advances in diagnosis and treatment of the disease, the prognosis of glioma is poor. Therefore, there is a great need to identify new prognostic factors and potential immunotherapeutic targets. Members of the Nectin family of proteins are gaining significant attention as possible diagnostic and immunotherapeutic targets in many solid tumors, but they have not been extensively investigated in glial tumors. The aim of the present study was to evaluate the expression of Nectin-2 and Nectin-4 in glial tumors of different grades, and to assess their prognostic value. The results showed heterogeneous expression of Nectin-2 and Nectin-4 in tumor cells and neuropil, with significantly higher Nectin-2 expression compared to Nectin-4, but without differences among tumor grades. In addition, the expression of Nectin-2 and Nectin-4 was associated with shorter survival times in patients with grade II/III gliomas. These results suggest that Nectin-2 and Nectin-4 expression may be used as an independent prognostic indicator for patients with II/III gliomas. This study contributes to the development of personalized care for patients with glioma and provides a basis for further research on nectin-based immunotherapy for brain tumors.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPathology - Research and Practice
Brojčani podacivol. 244, 154416
p-ISSN0344-0338
DOIhttps://doi.org/10.1016/j.prp.2023.154416
URN:NBNurn:nbn:hr:184:054240
Datum objave publikacije2023-04
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0344033823001164
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-08-23 07:41:37