prikaz prve stranice dokumenta The Significance of Heat-Shock Protein GP96 and its Receptors' CD91 and Toll-Like Receptor 4 Expression at the Maternal Foetal Interface
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Scientific paper - Original scientific paper
The Significance of Heat-Shock Protein GP96 and its Receptors' CD91 and Toll-Like Receptor 4 Expression at the Maternal Foetal Interface
American Journal of Reproductive Immunology, 70 (2013), 1; 10-23. https://doi.org/10.1111/aji.12096
Gulić, Tamara; Laškarin, Gordana; Redžovic, Arnela; Eminović, Senija; Haller, Herman; Rukavina, Daniel

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Gulić, T., Laškarin, G., Redžovic, A., Eminović, S., Haller, H. & Rukavina, D. (2013). The Significance of Heat-Shock Protein GP96 and its Receptors' CD91 and Toll-Like Receptor 4 Expression at the Maternal Foetal Interface. American Journal of Reproductive Immunology, 70. (1), 10-23. doi: 10.1111/aji.12096

Gulić, Tamara, et al. "The Significance of Heat-Shock Protein GP96 and its Receptors' CD91 and Toll-Like Receptor 4 Expression at the Maternal Foetal Interface." American Journal of Reproductive Immunology, vol. 70, no. 1, 2013, pp. 10-23. https://doi.org/10.1111/aji.12096

Gulić, Tamara, Gordana Laškarin, Arnela Redžovic, Senija Eminović, Herman Haller and Daniel Rukavina. "The Significance of Heat-Shock Protein GP96 and its Receptors' CD91 and Toll-Like Receptor 4 Expression at the Maternal Foetal Interface." American Journal of Reproductive Immunology 70, no. 1 (2013): 10-23. https://doi.org/10.1111/aji.12096

Gulić, T., et al. (2013) 'The Significance of Heat-Shock Protein GP96 and its Receptors' CD91 and Toll-Like Receptor 4 Expression at the Maternal Foetal Interface', American Journal of Reproductive Immunology, 70(1), pp. 10-23. doi: 10.1111/aji.12096

Gulić T, Laškarin G, Redžovic A, Eminović S, Haller H, Rukavina D. The Significance of Heat-Shock Protein GP96 and its Receptors' CD91 and Toll-Like Receptor 4 Expression at the Maternal Foetal Interface. American Journal of Reproductive Immunology [Internet]. 2013 July [cited 2024 November 12];70(1):10-23. doi: 10.1111/aji.12096

T. Gulić, G. Laškarin, A. Redžovic, S. Eminović, H. Haller and D. Rukavina, "The Significance of Heat-Shock Protein GP96 and its Receptors' CD91 and Toll-Like Receptor 4 Expression at the Maternal Foetal Interface", American Journal of Reproductive Immunology, vol. 70, no. 1, pp. 10-23, July 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:654113. [Accessed: 12 November 2024]

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Metadata
Title (english)The Significance of Heat-Shock Protein GP96 and its Receptors' CD91 and Toll-Like Receptor 4 Expression at the Maternal Foetal Interface
AuthorTamara Gulić
AuthorGordana Laškarin
AuthorArnela Redžovic
AuthorSenija Eminović
AuthorHerman Haller
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Problem: Differences in the expression of gp96 and its receptors were analysed in normal and pathological human pregnancy. Material and Methods: Immunohistology and immunofluorescence of sections from decidual part of term placenta, first trimester normal decidua, missed abortion and blighted ovum decidua were performed together with reverse transcriptase-quantitative polymerase chain reaction and flow cytometry. Results: In missed abortion, gp96 was intensively stained, when compared to normal early pregnancy. The intensity of CD91 and TLR4 was higher in the first trimester pregnancy and blighted ovum, when compared to missed abortion. Decidual part of the term placenta is invaded with gp96+, CD91+ and TLR4+ trophoblast. Progesterone-induced blocking factor (PIBF) decreased the frequency of TLR4+ T lymphocytes, CD91+ T, natural killer (NK) and mature dendritic cells after an 18-h culture. Decidual mononuclear cells (DMCs) treated with PIBF down-regulated CD91, TLR4 and gp96 gene expression. Conclusion: The presence of gp96, CD91 and TLR4 at the maternal-foetal interface provides a molecular basis for their interaction, particularly in the absence of PIBF.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAmerican Journal of Reproductive Immunology
Numberingvol. 70, no. 1, pp. 10-23
p-ISSN1046-7408
DOIhttps://doi.org/10.1111/aji.12096
URN:NBNurn:nbn:hr:184:654113
Publication2013-07
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/aji.12096
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2023-06-30 08:09:08