prikaz prve stranice dokumenta Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management
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Scientific paper - Original scientific paper
Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management
eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine, 32 (2021), 2; 280-285. urn:nbn:hr:184:894462
Šimac, Maja; Šimac, Daniel Victor; Bilić-Zulle, Lidija

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Šimac, M., Šimac, D. V. & Bilić Zulle, L. (2021). Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management. eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine, 32. (2), 280-285. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:894462

Šimac, Maja, et al. "Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management." eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine, vol. 32, no. 2, 2021, pp. 280-285. https://urn.nsk.hr/urn:nbn:hr:184:894462

Šimac, Maja, Daniel Victor Šimac and Lidija Bilić Zulle. "Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management." eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine 32, no. 2 (2021): 280-285. https://urn.nsk.hr/urn:nbn:hr:184:894462

Šimac, M., Šimac, D. V. and Bilić Zulle, L. (2021) 'Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management', eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine, 32(2), pp. 280-285. Available at: https://urn.nsk.hr/urn:nbn:hr:184:894462 (Accessed 05 May 2024)

Šimac M, Šimac DV, Bilić Zulle L. Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management. eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine [Internet]. 2021 [cited 2024 May 05];32(2):280-285. Available at: https://urn.nsk.hr/urn:nbn:hr:184:894462

M. Šimac, D. V. Šimac and L. Bilić Zulle, "Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management", eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine, vol. 32, no. 2, pp. 280-285, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:894462. [Accessed: 05 May 2024]

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Metadata
Title (english)Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management
AuthorMaja Šimac
AuthorDaniel Victor Šimac
AuthorLidija Bilić-Zulle
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Medical Informatics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Introduction: Rheumatoid arthritis (RA) treatment can be hepatotoxic, but liver enzymes can be falsely elevated due to macroenzyme presence. Macroenzymes are often found in autoimmune diseases, but prevalence and effect on treatment is unclear. This study aimed to determine aminotransferase macroenzyme prevalence and effect in RA patients. Materials and methods: This study included consecutive RA patients without liver disease sent for laboratory tests. Samples with elevated AST or ALT were processed for macroenzymes. Presence was determined using polyethylene glycol precipitation (PEG). Results: Out of 126 patients, 21 had elevated aminotransferase levels. Due to liver disease, 6 patients were excluded, another 3 were unavailable for informed consent, leaving 12 patients for inclusion. Out of 12 patients, 1 had increased AST levels, 2 increased ALT levels, and 9 both. Macro- ALT was detected in 5/11 patients, 1 also had macro-AST. Out of 5 patients with macroenzymes, treatment change was seen in 3/5 patients, imaging in 2/5, both in 2/5. Conclusion: Elevated liver enzymes in RA patients is not always indicative of hepatotoxicity, as shown by the fact that about half of patients in our study had macroenzymes detected. Before assuming drug hepatotoxicity and changing treatment or ordering imaging, rheumatologists could consider macroenzyme presence.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleeJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine
Numberingvol. 32, no. 2, pp. 280-285
e-ISSN1650-3414
URN:NBNurn:nbn:hr:184:894462
Publication2021
Document URLhttp://bib.irb.hr/1251760
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-02-07 08:38:02