prikaz prve stranice dokumenta Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management
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Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management
eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine, 32 (2021), 2; 280-285. urn:nbn:hr:184:894462
Šimac, Maja; Šimac, Daniel Victor; Bilić-Zulle, Lidija

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Šimac, M., Šimac, D. V. i Bilić Zulle, L. (2021). Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management. eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine, 32. (2), 280-285. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:894462

Šimac, Maja, et al. "Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management." eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine, vol. 32, br. 2, 2021, str. 280-285. https://urn.nsk.hr/urn:nbn:hr:184:894462

Šimac, Maja, Daniel Victor Šimac i Lidija Bilić Zulle. "Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management." eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine 32, br. 2 (2021): 280-285. https://urn.nsk.hr/urn:nbn:hr:184:894462

Šimac, M., Šimac, D. V. i Bilić Zulle, L. (2021) 'Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management', eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine, 32(2), str. 280-285. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:894462 (Datum pristupa: 07.05.2024.)

Šimac M, Šimac DV, Bilić Zulle L. Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management. eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine [Internet]. 2021. [pristupljeno 07.05.2024.];32(2):280-285. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:894462

M. Šimac, D. V. Šimac i L. Bilić Zulle, "Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management", eJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine, vol. 32, br. 2, str. 280-285, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:894462. [Citirano: 07.05.2024.]

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Naslov (engleski)Prevalence of Aminotransferase Macroenzymes in Rheumatoid Arthritis Patients and Impact on Their Management
AutorMaja Šimac
AutorDaniel Victor Šimac
AutorLidija Bilić-Zulle
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku informatiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Introduction: Rheumatoid arthritis (RA) treatment can be hepatotoxic, but liver enzymes can be falsely elevated due to macroenzyme presence. Macroenzymes are often found in autoimmune diseases, but prevalence and effect on treatment is unclear. This study aimed to determine aminotransferase macroenzyme prevalence and effect in RA patients. Materials and methods: This study included consecutive RA patients without liver disease sent for laboratory tests. Samples with elevated AST or ALT were processed for macroenzymes. Presence was determined using polyethylene glycol precipitation (PEG). Results: Out of 126 patients, 21 had elevated aminotransferase levels. Due to liver disease, 6 patients were excluded, another 3 were unavailable for informed consent, leaving 12 patients for inclusion. Out of 12 patients, 1 had increased AST levels, 2 increased ALT levels, and 9 both. Macro- ALT was detected in 5/11 patients, 1 also had macro-AST. Out of 5 patients with macroenzymes, treatment change was seen in 3/5 patients, imaging in 2/5, both in 2/5. Conclusion: Elevated liver enzymes in RA patients is not always indicative of hepatotoxicity, as shown by the fact that about half of patients in our study had macroenzymes detected. Before assuming drug hepatotoxicity and changing treatment or ordering imaging, rheumatologists could consider macroenzyme presence.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaeJIFCC : ejournal International Federation of Clinical Chemistry and Laboratory Medicine
Brojčani podacivol. 32, br. 2, str. 280-285
e-ISSN1650-3414
URN:NBNurn:nbn:hr:184:894462
Datum objave publikacije2021
URL dokumentahttp://bib.irb.hr/1251760
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-02-07 08:38:02