prikaz prve stranice dokumenta Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study
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Scientific paper - Original scientific paper
Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study
Diagnostics, 12 (2022), 6; 1358. https://doi.org/10.3390/diagnostics12061358
Schenke, Simone Agnes; Campennì, Alfredo; Tuncel, Murat; Bottoni, Gianluca; Sager, Sait; Bogović Crnčić, Tatjana; Rožić, Damir; Görges, Rainer; Özcan, Pinar Pelin; Groener, Daniel; Hautzel, Hubertus; Klett, Rigobert; Kreissl, Michael Christoph; Giovanella, Luca

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Schenke, S. A., Campennì, A., Tuncel, M., Bottoni, G., Sager, S., Bogović Crnčić, T. ... Giovanella, L. (2022). Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study. Diagnostics, 12. (6). doi: 10.3390/diagnostics12061358

Schenke, Simone Agnes, et al. "Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study." Diagnostics, vol. 12, no. 6, 2022. https://doi.org/10.3390/diagnostics12061358

Schenke, Simone Agnes, Alfredo Campennì, Murat Tuncel, Gianluca Bottoni, Sait Sager, Tatjana Bogović Crnčić, Damir Rožić, et al. "Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study." Diagnostics 12, no. 6 (2022). https://doi.org/10.3390/diagnostics12061358

Schenke, S. A., et al. (2022) 'Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study', Diagnostics, 12(6). doi: 10.3390/diagnostics12061358

Schenke SA, Campennì A, Tuncel M, Bottoni G, Sager S, Bogović Crnčić T, and sur.. Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study. Diagnostics [Internet]. 2022 May 31 [cited 2024 November 15];12(6). doi: 10.3390/diagnostics12061358

S. A. Schenke, et al., "Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study", Diagnostics, vol. 12, no. 6, May 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:505065. [Accessed: 15 November 2024]

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Title (english)Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study
AuthorSimone Agnes Schenke
AuthorAlfredo Campennì
AuthorMurat Tuncel
AuthorGianluca Bottoni
AuthorSait Sager
AuthorTatjana Bogović Crnčić
AuthorDamir Rožić
AuthorRainer Görges
AuthorPinar Pelin Özcan
AuthorDaniel Groener
AuthorHubertus Hautzel
AuthorRigobert Klett
AuthorMichael Christoph Kreissl
AuthorLuca Giovanella
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Nuclear Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Nuclear Medicine
Abstract (english)
99mTc-MIBI (MIBI) imaging is able to exclude malignancy of hypofunctioning thyroid nodules (TNs) with high probability but false positive results are frequent due to low specificity. Therefore, pre-test selection of appropriate TNs is crucial. For image evaluation visual and semiquantitative methods (Washout index, WOInd) are used. Aim of this study was to evaluate the diagnostic performance of MIBI imaging in hypofunctioning TNs with indeterminate fine-needle aspiration cytology results in a multicentric European setting. Patients with hypofunctioning TNs, EU-TIRADS 4 or 5, Bethesda III/IV and MIBI imaging were included. For visual evaluation the intensity of MIBI uptake in the TN was compared to normal thyroid tissue. 358 patients with 365 TNs (n = 68 malignant) were included. Planar imaging (SPECT) showed a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 96% (94%), 21% (22%), 22% (15%), 96% (96%), and 35% (32%). The WOInd (38.9% of all cases, optimal cutoff: −19%) showed a sens 100% (spec 89%, PPV 82%, NPV 100%, ACC 93%). For hypofunctioning TNs at intermediate or high risk with indeterminate cytology, a MIBI negative result on visual evaluation is an effective tool to rule-out thyroid malignancy. The semi-quantitative method could considerably improve overall diagnostic performance of MIBI imaging.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiagnostics
Numberingvol. 12, no. 6, 1358
e-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics12061358
URN:NBNurn:nbn:hr:184:505065
Publication2022-05-31
Document URLhttps://www.mdpi.com/2075-4418/12/6/1358
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-10-18 12:08:54