prikaz prve stranice dokumenta Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study
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Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study
Diagnostics, 12 (2022), 6; 1358. https://doi.org/10.3390/diagnostics12061358
Schenke, Simone Agnes; Campennì, Alfredo; Tuncel, Murat; Bottoni, Gianluca; Sager, Sait; Bogović Crnčić, Tatjana; Rožić, Damir; Görges, Rainer; Özcan, Pinar Pelin; Groener, Daniel; Hautzel, Hubertus; Klett, Rigobert; Kreissl, Michael Christoph; Giovanella, Luca

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Schenke, S. A., Campennì, A., Tuncel, M., Bottoni, G., Sager, S., Bogović Crnčić, T. ... Giovanella, L. (2022). Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study. Diagnostics, 12. (6). doi: 10.3390/diagnostics12061358

Schenke, Simone Agnes, et al. "Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study." Diagnostics, vol. 12, br. 6, 2022. https://doi.org/10.3390/diagnostics12061358

Schenke, Simone Agnes, Alfredo Campennì, Murat Tuncel, Gianluca Bottoni, Sait Sager, Tatjana Bogović Crnčić, Damir Rožić, et al. "Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study." Diagnostics 12, br. 6 (2022). https://doi.org/10.3390/diagnostics12061358

Schenke, S. A., et al. (2022) 'Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study', Diagnostics, 12(6). doi: 10.3390/diagnostics12061358

Schenke SA, Campennì A, Tuncel M, Bottoni G, Sager S, Bogović Crnčić T, i sur.. Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study. Diagnostics [Internet]. 31.05.2022. [pristupljeno 19.11.2024.];12(6). doi: 10.3390/diagnostics12061358

S. A. Schenke, et al., "Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study", Diagnostics, vol. 12, br. 6, Svibanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:505065. [Citirano: 19.11.2024.]

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Naslov (engleski)Diagnostic Performance of 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) for Risk Stratification of Hypofunctioning Thyroid Nodules: A European Multicenter Study
AutorSimone Agnes Schenke
AutorAlfredo Campennì
AutorMurat Tuncel
AutorGianluca Bottoni
AutorSait Sager
AutorTatjana Bogović Crnčić
AutorDamir Rožić
AutorRainer Görges
AutorPinar Pelin Özcan
AutorDaniel Groener
AutorHubertus Hautzel
AutorRigobert Klett
AutorMichael Christoph Kreissl
AutorLuca Giovanella
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za nuklearnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Nuklearna medicina
Sažetak (engleski)
99mTc-MIBI (MIBI) imaging is able to exclude malignancy of hypofunctioning thyroid nodules (TNs) with high probability but false positive results are frequent due to low specificity. Therefore, pre-test selection of appropriate TNs is crucial. For image evaluation visual and semiquantitative methods (Washout index, WOInd) are used. Aim of this study was to evaluate the diagnostic performance of MIBI imaging in hypofunctioning TNs with indeterminate fine-needle aspiration cytology results in a multicentric European setting. Patients with hypofunctioning TNs, EU-TIRADS 4 or 5, Bethesda III/IV and MIBI imaging were included. For visual evaluation the intensity of MIBI uptake in the TN was compared to normal thyroid tissue. 358 patients with 365 TNs (n = 68 malignant) were included. Planar imaging (SPECT) showed a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 96% (94%), 21% (22%), 22% (15%), 96% (96%), and 35% (32%). The WOInd (38.9% of all cases, optimal cutoff: −19%) showed a sens 100% (spec 89%, PPV 82%, NPV 100%, ACC 93%). For hypofunctioning TNs at intermediate or high risk with indeterminate cytology, a MIBI negative result on visual evaluation is an effective tool to rule-out thyroid malignancy. The semi-quantitative method could considerably improve overall diagnostic performance of MIBI imaging.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDiagnostics
Brojčani podacivol. 12, br. 6, 1358
e-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics12061358
URN:NBNurn:nbn:hr:184:505065
Datum objave publikacije2022-05-31
URL dokumentahttps://www.mdpi.com/2075-4418/12/6/1358
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-10-18 12:08:54