prikaz prve stranice dokumenta Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer
  Download
PDF 66.91 KB
Scientific paper - Original scientific paper
Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer
Collegium antropologicum, 34 supplement 2 (2010), 2; 149-153. urn:nbn:hr:184:447026
Markić, Dean; Ćelić, Tanja; Španjol, Josip; Gršković, Antun; Bobinac, Dragica; Fučkar, Željko

Cite this document

Markić, D., Ćelić, T., Španjol, J., Gršković, A., Bobinac, D. & Fučkar, Ž. (2010). Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer. Collegium antropologicum, 34 supplement 2. (2), 149-153. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:447026

Markić, Dean, et al. "Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer." Collegium antropologicum, vol. 34 supplement 2, no. 2, 2010, pp. 149-153. https://urn.nsk.hr/urn:nbn:hr:184:447026

Markić, Dean, Tanja Ćelić, Josip Španjol, Antun Gršković, Dragica Bobinac and Željko Fučkar. "Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer." Collegium antropologicum 34 supplement 2, no. 2 (2010): 149-153. https://urn.nsk.hr/urn:nbn:hr:184:447026

Markić, D., et al. (2010) 'Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer', Collegium antropologicum, 34 supplement 2(2), pp. 149-153. Available at: https://urn.nsk.hr/urn:nbn:hr:184:447026 (Accessed 14 November 2024)

Markić D, Ćelić T, Španjol J, Gršković A, Bobinac D, Fučkar Ž. Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer. Collegium antropologicum [Internet]. 2010 [cited 2024 November 14];34 supplement 2(2):149-153. Available at: https://urn.nsk.hr/urn:nbn:hr:184:447026

D. Markić, T. Ćelić, J. Španjol, A. Gršković, D. Bobinac and Ž. Fučkar, "Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer", Collegium antropologicum, vol. 34 supplement 2, no. 2, pp. 149-153, 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:447026. [Accessed: 14 November 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer
AuthorDean Markić
AuthorTanja Ćelić
AuthorJosip Španjol
AuthorAntun Gršković
AuthorDragica Bobinac
AuthorŽeljko Fučkar
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract (english)
Bone morphogenetic proteins (BMPs) are cytokines which are important for kidney homeostasis but also have role in the some renal diseases and renal cell carcinoma (RCC)1–5. In the last three decades incidence of RCC was constantly increased and the role of different molecular biomarkers in RCC is explored1. We analyzed expression of BMP-7, their receptors (BMPR-IA, BMPR-IB, BMPR-II) and proteins of their signaling pathway (pSmad1/5/8) in sixteen renal cancer samples and paired normal tissue. Tissue samples were analyzed by immunohistochemistry and Western blot. BMP-7, BMP receptors and pSmad1/5/8 were expressed in all structures of normal kidney but dominantly in the proximal tubular cells. In the cancer samples their expression was also noticed. Comparison of BMPs between different tissue showed increased expression of BMPR-IB and pSmad 1/5/8 and decreased expression of BMP-7 and BMPR-II in RCC compared to normal kidney. BMPR-IA was detected with immunohistochemistry but with Western blot attenuated signal was presented. BMP-7, BMP receptors and pSmad1/5/8 were showed in normal kidney and RCC. Detected alterations of BMP-7, BMP receptors and pSmad expression in RCC suggested their possible role in tumorigenesis of kidney cancer.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 34 supplement 2, no. 2, pp. 149-153
p-ISSN0350-6134
e-ISSN1848-9486
URN:NBNurn:nbn:hr:184:447026
Publication2010
Document URLhttps://hrcak.srce.hr/51648
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-04-01 14:48:53