prikaz prve stranice dokumenta Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer
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Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer
Collegium antropologicum, 34 supplement 2 (2010), 2; 149-153. urn:nbn:hr:184:447026
Markić, Dean; Ćelić, Tanja; Španjol, Josip; Gršković, Antun; Bobinac, Dragica; Fučkar, Željko

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Markić, D., Ćelić, T., Španjol, J., Gršković, A., Bobinac, D. i Fučkar, Ž. (2010). Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer. Collegium antropologicum, 34 supplement 2. (2), 149-153. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:447026

Markić, Dean, et al. "Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer." Collegium antropologicum, vol. 34 supplement 2, br. 2, 2010, str. 149-153. https://urn.nsk.hr/urn:nbn:hr:184:447026

Markić, Dean, Tanja Ćelić, Josip Španjol, Antun Gršković, Dragica Bobinac i Željko Fučkar. "Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer." Collegium antropologicum 34 supplement 2, br. 2 (2010): 149-153. https://urn.nsk.hr/urn:nbn:hr:184:447026

Markić, D., et al. (2010) 'Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer', Collegium antropologicum, 34 supplement 2(2), str. 149-153. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:447026 (Datum pristupa: 25.10.2024.)

Markić D, Ćelić T, Španjol J, Gršković A, Bobinac D, Fučkar Ž. Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer. Collegium antropologicum [Internet]. 2010. [pristupljeno 25.10.2024.];34 supplement 2(2):149-153. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:447026

D. Markić, T. Ćelić, J. Španjol, A. Gršković, D. Bobinac i Ž. Fučkar, "Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer", Collegium antropologicum, vol. 34 supplement 2, br. 2, str. 149-153, 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:447026. [Citirano: 25.10.2024.]

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Naslov (engleski)Expression of Bone Morphogenetic Protein-7, It´s Receptors and Smad1/5/8 in Normal Human Kidney and Renal Cell Cancer
AutorDean Markić
AutorTanja Ćelić
AutorJosip Španjol
AutorAntun Gršković
AutorDragica Bobinac
AutorŽeljko Fučkar
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anatomiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za urologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Urologija
Sažetak (engleski)
Bone morphogenetic proteins (BMPs) are cytokines which are important for kidney homeostasis but also have role in the some renal diseases and renal cell carcinoma (RCC)1–5. In the last three decades incidence of RCC was constantly increased and the role of different molecular biomarkers in RCC is explored1. We analyzed expression of BMP-7, their receptors (BMPR-IA, BMPR-IB, BMPR-II) and proteins of their signaling pathway (pSmad1/5/8) in sixteen renal cancer samples and paired normal tissue. Tissue samples were analyzed by immunohistochemistry and Western blot. BMP-7, BMP receptors and pSmad1/5/8 were expressed in all structures of normal kidney but dominantly in the proximal tubular cells. In the cancer samples their expression was also noticed. Comparison of BMPs between different tissue showed increased expression of BMPR-IB and pSmad 1/5/8 and decreased expression of BMP-7 and BMPR-II in RCC compared to normal kidney. BMPR-IA was detected with immunohistochemistry but with Western blot attenuated signal was presented. BMP-7, BMP receptors and pSmad1/5/8 were showed in normal kidney and RCC. Detected alterations of BMP-7, BMP receptors and pSmad expression in RCC suggested their possible role in tumorigenesis of kidney cancer.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCollegium antropologicum
Brojčani podacivol. 34 supplement 2, br. 2, str. 149-153
p-ISSN0350-6134
e-ISSN1848-9486
URN:NBNurn:nbn:hr:184:447026
Datum objave publikacije2010
URL dokumentahttps://hrcak.srce.hr/51648
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-04-01 14:48:53