prikaz prve stranice dokumenta Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse
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Scientific paper - Original scientific paper
Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse
Physiological Research, 1 (2006); 89-96. https://doi.org/10.33549/physiolres.930739
Muhvić-Urek, Miranda; Bralić, Marina; Curic, C; Pezelj-Ribarić, Sonja; Borčić, Josipa; Tomac, Jelena

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Muhvić Urek, M., Bralić, M., Curic, C., Pezelj Ribarić, S., Borčić, J. & Tomac, J. (2006). Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse. Physiological Research, 1., 89-96. doi: 10.33549/physiolres.930739

Muhvić Urek, Miranda, et al. "Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse." Physiological Research, vol. 1, 2006, pp. 89-96. https://doi.org/10.33549/physiolres.930739

Muhvić Urek, Miranda, Marina Bralić, C Curic, Sonja Pezelj Ribarić, Josipa Borčić and Jelena Tomac. "Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse." Physiological Research 1 (2006): 89-96. https://doi.org/10.33549/physiolres.930739

Muhvić Urek, M., et al. (2006) 'Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse', Physiological Research, 1, pp. 89-96. doi: 10.33549/physiolres.930739

Muhvić Urek M, Bralić M, Curic C, Pezelj Ribarić S, Borčić J, Tomac J. Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse. Physiological Research [Internet]. 2006 [cited 2025 January 23];1:89-96. doi: 10.33549/physiolres.930739

M. Muhvić Urek, M. Bralić, C. Curic, S. Pezelj Ribarić, J. Borčić and J. Tomac, "Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse", Physiological Research, vol. 1, pp. 89-96, 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:380556. [Accessed: 23 January 2025]

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Metadata
Title (english)Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse
AuthorMiranda Muhvić-Urek
AuthorMarina Bralić
AuthorC Curic
AuthorSonja Pezelj-Ribarić
AuthorJosipa Borčić
AuthorJelena Tomac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Severe xerostomia is a common late radiation consequence, which occurs after irradiation of head and neck malignancies. The aim of the present study was to analyze apoptosis and proliferation and their relationship during the late post-irradiation phase. C57BL/6 mice were locally irradiated in head and neck region with a single dose of 7.5 or 15 Gy and their submandibular glands were collected at 40 and 90 days after irradiation. To identify apoptotic cells, the TUNEL method was employed and immunohistochemistry with proliferating cell nuclear antigen (PCNA) was used for detecting proliferation. Histological changes at day 40 were mild in contrast to day 90 when glands of irradiated mice showed severe atrophy, vacuolization and mononuclear infiltration. Acinar cells, granular and intercalated duct cells of mice irradiated with 7.5 and 15 Gy expressed higher apoptotic index than cells of non-irradiated, control glands at both examined time points. At 40 days, a higher proliferation index in granular and intercalated duct cells was detected only in group irradiated with 7.5 Gy. At 90 days, proliferation index for all cell types in both irradiated groups was similar to the controls. According to our results, the imbalance between apoptosis and proliferation caused by X-irradiation may be the reason for gland impairment during the late post-irradiation phase.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePhysiological Research
Numberingvol. 1, pp. 89-96
p-ISSN0862-8408
e-ISSN1802-9973
DOIhttps://doi.org/10.33549/physiolres.930739
URN:NBNurn:nbn:hr:184:380556
Publication2006
Document URLhttps://www.biomed.cas.cz/physiolres/pdf/55/55_89.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2022-03-18 14:16:08