prikaz prve stranice dokumenta Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse
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Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse
Physiological Research, 1 (2006); 89-96. https://doi.org/10.33549/physiolres.930739
Muhvić-Urek, Miranda; Bralić, Marina; Curic, C; Pezelj-Ribarić, Sonja; Borčić, Josipa; Tomac, Jelena

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Muhvić Urek, M., Bralić, M., Curic, C., Pezelj Ribarić, S., Borčić, J. i Tomac, J. (2006). Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse. Physiological Research, 1., 89-96. doi: 10.33549/physiolres.930739

Muhvić Urek, Miranda, et al. "Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse." Physiological Research, vol. 1, 2006, str. 89-96. https://doi.org/10.33549/physiolres.930739

Muhvić Urek, Miranda, Marina Bralić, C Curic, Sonja Pezelj Ribarić, Josipa Borčić i Jelena Tomac. "Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse." Physiological Research 1 (2006): 89-96. https://doi.org/10.33549/physiolres.930739

Muhvić Urek, M., et al. (2006) 'Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse', Physiological Research, 1, str. 89-96. doi: 10.33549/physiolres.930739

Muhvić Urek M, Bralić M, Curic C, Pezelj Ribarić S, Borčić J, Tomac J. Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse. Physiological Research [Internet]. 2006. [pristupljeno 28.10.2024.];1:89-96. doi: 10.33549/physiolres.930739

M. Muhvić Urek, M. Bralić, C. Curic, S. Pezelj Ribarić, J. Borčić i J. Tomac, "Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse", Physiological Research, vol. 1, str. 89-96, 2006. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:380556. [Citirano: 28.10.2024.]

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Naslov (engleski)Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse
AutorMiranda Muhvić-Urek
AutorMarina Bralić
AutorC Curic
AutorSonja Pezelj-Ribarić
AutorJosipa Borčić
AutorJelena Tomac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Severe xerostomia is a common late radiation consequence, which occurs after irradiation of head and neck malignancies. The aim of the present study was to analyze apoptosis and proliferation and their relationship during the late post-irradiation phase. C57BL/6 mice were locally irradiated in head and neck region with a single dose of 7.5 or 15 Gy and their submandibular glands were collected at 40 and 90 days after irradiation. To identify apoptotic cells, the TUNEL method was employed and immunohistochemistry with proliferating cell nuclear antigen (PCNA) was used for detecting proliferation. Histological changes at day 40 were mild in contrast to day 90 when glands of irradiated mice showed severe atrophy, vacuolization and mononuclear infiltration. Acinar cells, granular and intercalated duct cells of mice irradiated with 7.5 and 15 Gy expressed higher apoptotic index than cells of non-irradiated, control glands at both examined time points. At 40 days, a higher proliferation index in granular and intercalated duct cells was detected only in group irradiated with 7.5 Gy. At 90 days, proliferation index for all cell types in both irradiated groups was similar to the controls. According to our results, the imbalance between apoptosis and proliferation caused by X-irradiation may be the reason for gland impairment during the late post-irradiation phase.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPhysiological Research
Brojčani podacivol. 1, str. 89-96
p-ISSN0862-8408
e-ISSN1802-9973
DOIhttps://doi.org/10.33549/physiolres.930739
URN:NBNurn:nbn:hr:184:380556
Datum objave publikacije2006
URL dokumentahttps://www.biomed.cas.cz/physiolres/pdf/55/55_89.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2022-03-18 14:16:08