prikaz prve stranice dokumenta The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients
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Scientific paper - Original scientific paper
The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients
Minerva anestesiologica, 84 (2018), 9; 1032-1043. urn:nbn:hr:184:096077
Belavić, Matija; Sotošek Tokmadžić, Vlatka; Fišić, Elizabeta; Brozović Krijan, Antonija; Strikić, Nedjeljko; Lončarić Katušin, Mirjana; Žunić, Josip

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Belavić, M., Sotošek Tokmadžić, V., Fišić, E., Brozović Krijan, A., Strikić, N., Lončarić Katušin, M. & Žunić, J. (2018). The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients. Minerva anestesiologica, 84. (9), 1032-1043. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:096077

Belavić, Matija, et al. "The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients." Minerva anestesiologica, vol. 84, no. 9, 2018, pp. 1032-1043. https://urn.nsk.hr/urn:nbn:hr:184:096077

Belavić, Matija, Vlatka Sotošek Tokmadžić, Elizabeta Fišić, Antonija Brozović Krijan, Nedjeljko Strikić, Mirjana Lončarić Katušin and Josip Žunić. "The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients." Minerva anestesiologica 84, no. 9 (2018): 1032-1043. https://urn.nsk.hr/urn:nbn:hr:184:096077

Belavić, M., et al. (2018) 'The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients', Minerva anestesiologica, 84(9), pp. 1032-1043. Available at: https://urn.nsk.hr/urn:nbn:hr:184:096077 (Accessed 19 March 2025)

Belavić M, Sotošek Tokmadžić V, Fišić E, Brozović Krijan A, Strikić N, Lončarić Katušin M, and sur.. The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients. Minerva anestesiologica [Internet]. 2018 [cited 2025 March 19];84(9):1032-1043. Available at: https://urn.nsk.hr/urn:nbn:hr:184:096077

M. Belavić, et al., "The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients", Minerva anestesiologica, vol. 84, no. 9, pp. 1032-1043, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:096077. [Accessed: 19 March 2025]

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Metadata
Title (english)The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients
AuthorMatija Belavić
MBZ: 373166
AuthorVlatka Sotošek Tokmadžić
AuthorElizabeta Fišić
MBZ: 253916
AuthorAntonija Brozović Krijan
AuthorNedjeljko Strikić
MBZ: 245460
AuthorMirjana Lončarić Katušin
AuthorJosip Žunić
MBZ: 243926
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Abstract (english)
BACKGROUND: The endothelial glycocalyx is located on the luminal side of blood vessels and maintains vessel integrity. This study analysed how various dosages of infusion affected the secretion of atrial natriuretic peptide (ANP) and potential glycocalyx damage in patients undergoing laparoscopic cholecystectomy. We hypothesised that the liberal administration of Ringer's solution during the operation can cause iatrogenic hypervolemia with releasing of ANP and glycocalyx damage. METHODS: The study included 90 patients with American Society of Anesthesiologists' (ASA) class I and II, in good cardiopulmonary health, who were assigned to one of three groups: Restrictive group, which received 1 mL/kg/hr intraoperatively and six hours postoperatively ; Low liberal group, which received 5 mL/kg/hr of Ringer's solution intraoperatively and six hours postoperatively and High liberal group, which received 15 mL/kg/hr intraoperatively and 10 mL/kg/hr six hours postoperatively. We measured patients' concentrations of glycocalyx constituents, ANP, markers of kidney and liver function, C- reactive protein (CRP), and albumine at three time points. We also measured noinvasive hemodynamics, the correlation between ANP secretion and the concentration of glycocalyx components. RESULTS: We found a significantly higher concentrations of hyaluronic acid and syndecan-1 and more ANP secretion in the High liberal group than in the other groups. We also observed a positive correlation between ANP secretion and glycocalyx constituent concentration. Markers of kidney and liver function were normal, suggesting preservation of splanchnic perfusion and global hemodynamics. CONCLUSIONS: Measuring the endothelial glycocalyx constituents in circulating blood could be a marker of intraoperative volume overload during laparoscopic operations.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMinerva anestesiologica
Numberingvol. 84, no. 9, pp. 1032-1043
p-ISSN0375-9393
URN:NBNurn:nbn:hr:184:096077
Publication2018
Document URLhttp://bib.irb.hr/968537
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-03-10 16:56:34