prikaz prve stranice dokumenta The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients
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The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients
Minerva anestesiologica, 84 (2018), 9; 1032-1043. urn:nbn:hr:184:096077
Belavić, Matija; Sotošek Tokmadžić, Vlatka; Fišić, Elizabeta; Brozović Krijan, Antonija; Strikić, Nedjeljko; Lončarić Katušin, Mirjana; Žunić, Josip

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Belavić, M., Sotošek Tokmadžić, V., Fišić, E., Brozović Krijan, A., Strikić, N., Lončarić Katušin, M. i Žunić, J. (2018). The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients. Minerva anestesiologica, 84. (9), 1032-1043. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:096077

Belavić, Matija, et al. "The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients." Minerva anestesiologica, vol. 84, br. 9, 2018, str. 1032-1043. https://urn.nsk.hr/urn:nbn:hr:184:096077

Belavić, Matija, Vlatka Sotošek Tokmadžić, Elizabeta Fišić, Antonija Brozović Krijan, Nedjeljko Strikić, Mirjana Lončarić Katušin i Josip Žunić. "The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients." Minerva anestesiologica 84, br. 9 (2018): 1032-1043. https://urn.nsk.hr/urn:nbn:hr:184:096077

Belavić, M., et al. (2018) 'The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients', Minerva anestesiologica, 84(9), str. 1032-1043. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:096077 (Datum pristupa: 17.11.2024.)

Belavić M, Sotošek Tokmadžić V, Fišić E, Brozović Krijan A, Strikić N, Lončarić Katušin M, i sur.. The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients. Minerva anestesiologica [Internet]. 2018. [pristupljeno 17.11.2024.];84(9):1032-1043. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:096077

M. Belavić, et al., "The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients", Minerva anestesiologica, vol. 84, br. 9, str. 1032-1043, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:096077. [Citirano: 17.11.2024.]

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Naslov (engleski)The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients
AutorMatija Belavić
MBZ: 373166
AutorVlatka Sotošek Tokmadžić
AutorElizabeta Fišić
MBZ: 253916
AutorAntonija Brozović Krijan
AutorNedjeljko Strikić
MBZ: 245460
AutorMirjana Lončarić Katušin
AutorJosip Žunić
MBZ: 243926
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Anesteziologija i reanimatologija
Sažetak (engleski)
BACKGROUND: The endothelial glycocalyx is located on the luminal side of blood vessels and maintains vessel integrity. This study analysed how various dosages of infusion affected the secretion of atrial natriuretic peptide (ANP) and potential glycocalyx damage in patients undergoing laparoscopic cholecystectomy. We hypothesised that the liberal administration of Ringer's solution during the operation can cause iatrogenic hypervolemia with releasing of ANP and glycocalyx damage. METHODS: The study included 90 patients with American Society of Anesthesiologists' (ASA) class I and II, in good cardiopulmonary health, who were assigned to one of three groups: Restrictive group, which received 1 mL/kg/hr intraoperatively and six hours postoperatively ; Low liberal group, which received 5 mL/kg/hr of Ringer's solution intraoperatively and six hours postoperatively and High liberal group, which received 15 mL/kg/hr intraoperatively and 10 mL/kg/hr six hours postoperatively. We measured patients' concentrations of glycocalyx constituents, ANP, markers of kidney and liver function, C- reactive protein (CRP), and albumine at three time points. We also measured noinvasive hemodynamics, the correlation between ANP secretion and the concentration of glycocalyx components. RESULTS: We found a significantly higher concentrations of hyaluronic acid and syndecan-1 and more ANP secretion in the High liberal group than in the other groups. We also observed a positive correlation between ANP secretion and glycocalyx constituent concentration. Markers of kidney and liver function were normal, suggesting preservation of splanchnic perfusion and global hemodynamics. CONCLUSIONS: Measuring the endothelial glycocalyx constituents in circulating blood could be a marker of intraoperative volume overload during laparoscopic operations.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMinerva anestesiologica
Brojčani podacivol. 84, br. 9, str. 1032-1043
p-ISSN0375-9393
URN:NBNurn:nbn:hr:184:096077
Datum objave publikacije2018
URL dokumentahttp://bib.irb.hr/968537
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
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Datum i vrijeme pohrane2022-03-10 16:56:34