prikaz prve stranice dokumenta Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis
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Scientific paper - Original scientific paper
Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis
Annals of the Rheumatic Diseases, 78 (2019), 9; 1242-1248. https://doi.org/10.1136/annrheumdis-2019-215145
(EUSTAR Collaboration) Becker, Mike; Graf, Nicole; Sauter, Rafael; ...; Novak, Srđan; ...; Martinović, Duška; ...; Anić, Branimir; Barešić, Marko; Mayer, Miroslav; ...

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Becker, M., Graf, N., Sauter, R., Novak, S., Martinović, D., Anić, B. ... Mayer, M. (2019). Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis. Annals of the Rheumatic Diseases, 78. (9), 1242-1248. doi: 10.1136/annrheumdis-2019-215145

Becker, Mike, et al. "Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis." Annals of the Rheumatic Diseases, vol. 78, no. 9, 2019, pp. 1242-1248. https://doi.org/10.1136/annrheumdis-2019-215145

Becker, Mike, Nicole Graf, Rafael Sauter, Srđan Novak, Duška Martinović, Branimir Anić, Marko Barešić and Miroslav Mayer. "Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis." Annals of the Rheumatic Diseases 78, no. 9 (2019): 1242-1248. https://doi.org/10.1136/annrheumdis-2019-215145

Becker, M., et al. (2019) 'Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis', Annals of the Rheumatic Diseases, 78(9), pp. 1242-1248. doi: 10.1136/annrheumdis-2019-215145

Becker M, Graf N, Sauter R, Novak S, Martinović D, Anić B, and sur.. Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis. Annals of the Rheumatic Diseases [Internet]. 2019 [cited 2024 November 17];78(9):1242-1248. doi: 10.1136/annrheumdis-2019-215145

M. Becker, et al., "Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis", Annals of the Rheumatic Diseases, vol. 78, no. 9, pp. 1242-1248, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:155836. [Accessed: 17 November 2024]

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Metadata
Title (english)Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis
AuthorMike Becker
AuthorNicole Graf
AuthorRafael Sauter
Author
...
AuthorSrđan Novak
Author
...
AuthorDuška Martinović
Author
...
AuthorBranimir Anić
MBZ: 140514
AuthorMarko Barešić
MBZ: 224326
AuthorMiroslav Mayer
MBZ: 383474
Author
...
CollaborationEUSTAR Collaboration
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
OBJECTIVES: Mortality and worsening of organ function are desirable endpoints for clinical trials in systemic sclerosis (SSc). The aim of this study was to identify factors that allow enrichment of patients with these endpoints, in a population of patients from the European Scleroderma Trials and Research group database. METHODS: Inclusion criteria were diagnosis of diffuse SSc and follow-up over 12±3 months. Disease worsening/organ progression was fulfilled if any of the following events occurred: new renal crisis ; decrease of lung or heart function ; new echocardiography- suspected pulmonary hypertension or death. In total, 42 clinical parameters were chosen as predictors for the analysis by using (1) imputation of missing data on the basis of multivariate imputation and (2) least absolute shrinkage and selection operator regression. RESULTS: Of 1451 patients meeting the inclusion criteria, 706 had complete data on outcome parameters and were included in the analysis. Of the 42 outcome predictors, eight remained in the final regression model. There was substantial evidence for a strong association between disease progression and age, active digital ulcer (DU), lung fibrosis, muscle weakness and elevated C- reactive protein (CRP) level. Active DU, CRP elevation, lung fibrosis and muscle weakness were also associated with a significantly shorter time to disease progression. A bootstrap validation step with 10 000 repetitions successfully validated the model. CONCLUSIONS: The use of the predictive factors presented here could enable cohort enrichment with patients at risk for overall disease worsening in SSc clinical trials.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleAnnals of the Rheumatic Diseases
Numberingvol. 78, no. 9, pp. 1242-1248
p-ISSN0003-4967
e-ISSN1468-2060
DOIhttps://doi.org/10.1136/annrheumdis-2019-215145
URN:NBNurn:nbn:hr:184:155836
Publication2019
Document URLhttp://bib.irb.hr/1029095
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-03-04 11:28:49