prikaz prve stranice dokumenta Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis
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Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis
Annals of the Rheumatic Diseases, 78 (2019), 9; 1242-1248. https://doi.org/10.1136/annrheumdis-2019-215145
(EUSTAR Collaboration) Becker, Mike; Graf, Nicole; Sauter, Rafael; ...; Novak, Srđan; ...; Martinović, Duška; ...; Anić, Branimir; Barešić, Marko; Mayer, Miroslav; ...

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Becker, M., Graf, N., Sauter, R., Novak, S., Martinović, D., Anić, B. ... Mayer, M. (2019). Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis. Annals of the Rheumatic Diseases, 78. (9), 1242-1248. doi: 10.1136/annrheumdis-2019-215145

Becker, Mike, et al. "Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis." Annals of the Rheumatic Diseases, vol. 78, br. 9, 2019, str. 1242-1248. https://doi.org/10.1136/annrheumdis-2019-215145

Becker, Mike, Nicole Graf, Rafael Sauter, Srđan Novak, Duška Martinović, Branimir Anić, Marko Barešić i Miroslav Mayer. "Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis." Annals of the Rheumatic Diseases 78, br. 9 (2019): 1242-1248. https://doi.org/10.1136/annrheumdis-2019-215145

Becker, M., et al. (2019) 'Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis', Annals of the Rheumatic Diseases, 78(9), str. 1242-1248. doi: 10.1136/annrheumdis-2019-215145

Becker M, Graf N, Sauter R, Novak S, Martinović D, Anić B, i sur.. Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis. Annals of the Rheumatic Diseases [Internet]. 2019. [pristupljeno 28.10.2024.];78(9):1242-1248. doi: 10.1136/annrheumdis-2019-215145

M. Becker, et al., "Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis", Annals of the Rheumatic Diseases, vol. 78, br. 9, str. 1242-1248, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:155836. [Citirano: 28.10.2024.]

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Podaci o radu
Naslov (engleski)Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis
AutorMike Becker
AutorNicole Graf
AutorRafael Sauter
Autor
...
AutorSrđan Novak
Autor
...
AutorDuška Martinović
Autor
...
AutorBranimir Anić
MBZ: 140514
AutorMarko Barešić
MBZ: 224326
AutorMiroslav Mayer
MBZ: 383474
Autor
...
KolaboracijaEUSTAR Collaboration
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
OBJECTIVES: Mortality and worsening of organ function are desirable endpoints for clinical trials in systemic sclerosis (SSc). The aim of this study was to identify factors that allow enrichment of patients with these endpoints, in a population of patients from the European Scleroderma Trials and Research group database. METHODS: Inclusion criteria were diagnosis of diffuse SSc and follow-up over 12±3 months. Disease worsening/organ progression was fulfilled if any of the following events occurred: new renal crisis ; decrease of lung or heart function ; new echocardiography- suspected pulmonary hypertension or death. In total, 42 clinical parameters were chosen as predictors for the analysis by using (1) imputation of missing data on the basis of multivariate imputation and (2) least absolute shrinkage and selection operator regression. RESULTS: Of 1451 patients meeting the inclusion criteria, 706 had complete data on outcome parameters and were included in the analysis. Of the 42 outcome predictors, eight remained in the final regression model. There was substantial evidence for a strong association between disease progression and age, active digital ulcer (DU), lung fibrosis, muscle weakness and elevated C- reactive protein (CRP) level. Active DU, CRP elevation, lung fibrosis and muscle weakness were also associated with a significantly shorter time to disease progression. A bootstrap validation step with 10 000 repetitions successfully validated the model. CONCLUSIONS: The use of the predictive factors presented here could enable cohort enrichment with patients at risk for overall disease worsening in SSc clinical trials.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAnnals of the Rheumatic Diseases
Brojčani podacivol. 78, br. 9, str. 1242-1248
p-ISSN0003-4967
e-ISSN1468-2060
DOIhttps://doi.org/10.1136/annrheumdis-2019-215145
URN:NBNurn:nbn:hr:184:155836
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1029095
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-03-04 11:28:49