prikaz prve stranice dokumenta Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia
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Scientific paper - Original scientific paper
Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia
International Journal of Cardiology, 119 (2016); 277-281. https://doi.org/10.1016/j.ijcard.2016.06.058
Boban, Marko; Žulj, Marinko; Peršić, Viktor; Medved, Igor; Zekanović, Dražen; Včev, Aleksandar

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Boban, M., Žulj, M., Peršić, V., Medved, I., Zekanović, D. & Včev, A. (2016). Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia. International Journal of Cardiology, 119., 277-281. doi: 10.1016/j.ijcard.2016.06.058

Boban, Marko, et al. "Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia." International Journal of Cardiology, vol. 119, 2016, pp. 277-281. https://doi.org/10.1016/j.ijcard.2016.06.058

Boban, Marko, Marinko Žulj, Viktor Peršić, Igor Medved, Dražen Zekanović and Aleksandar Včev. "Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia." International Journal of Cardiology 119 (2016): 277-281. https://doi.org/10.1016/j.ijcard.2016.06.058

Boban, M., et al. (2016) 'Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia', International Journal of Cardiology, 119, pp. 277-281. doi: 10.1016/j.ijcard.2016.06.058

Boban M, Žulj M, Peršić V, Medved I, Zekanović D, Včev A. Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia. International Journal of Cardiology [Internet]. 2016 [cited 2025 April 11];119:277-281. doi: 10.1016/j.ijcard.2016.06.058

M. Boban, M. Žulj, V. Peršić, I. Medved, D. Zekanović and A. Včev, "Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia", International Journal of Cardiology, vol. 119, pp. 277-281, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:522312. [Accessed: 11 April 2025]

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Title (english)Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia
AuthorMarko Boban
AuthorMarinko Žulj
AuthorViktor Peršić
AuthorIgor Medved
AuthorDražen Zekanović
AuthorAleksandar Včev
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Rehabilitatiom Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Proton pump inhibitors (PPIs) are among the commonest drugs used nowadays. The aim of our study was to analyze prolonged utilization of proton pump inhibitors in medical therapy of patients with ischemic and valvular heart disease. Secondly, profile of utilization was scrutinized to patient characteristics and type of cardiovascular treatments. The study included consecutive patients scheduled for cardiovascular rehabilitation 2–6 months after index cardiovascular treatment. Two hundred... More ninety-four patients (n = 294/604 ; 48.7%) have been using proton pump inhibitor in their therapy after index cardiovascular treatment. Cardiovascular treatments were powerfully connected with utilization of PPIs ; surgery 5.77 (95%-confidence intervals [CI]: 4.05–8.22 ; p < 0.001) and PCI 0.15 (CI: 0.10– 0.22 ; p < 0.001). The odds for having proton pump inhibitor in their chronic therapy were increased for atrial fibrillation 1.87 (CI: 1.08–3.23 ; p = 0.025) and decreased for obesity 0.65 (CI: 0.45–0.96 ; p = 0.035) ; surviving myocardial infarction 0.49 (CI: 0.29–0.83 ; p = 0.035). Multinomial logistic regression controlled for existence of chronic renal disease found no significant association of renal dysfunction and PPI therapy. The existence of anemia was significantly increased in patients taking PPIs than controls ; 6.00 (CI: 3.85–9.33 ; p < 0.001). The use of PPI was also associated with worsening of metabolic profile, in part due to decreased utilization of ACE-inhibitors and statins. PPI consumption correlated with age of patients (Rho = 0.216 ; p < 0.001). High proportion of cardiovascular, particularly surgical patients with ischemic and valvular heart disease utilized proton pump inhibitor in prolonged courses. Prolonged courses of PPIs were connected with existence and worsening of red blood count indexes, older age, lesser weight of patients and underutilization of cardioprotective drugs. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Cardiology
Numberingvol. 119, pp. 277-281
p-ISSN0167-5273
DOIhttps://doi.org/10.1016/j.ijcard.2016.06.058
URN:NBNurn:nbn:hr:184:522312
Publication2016
Document URLhttp://bib.irb.hr/887686
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-03-03 13:41:24
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