prikaz prve stranice dokumenta Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia
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Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia
International Journal of Cardiology, 119 (2016); 277-281. https://doi.org/10.1016/j.ijcard.2016.06.058
Boban, Marko; Žulj, Marinko; Peršić, Viktor; Medved, Igor; Zekanović, Dražen; Včev, Aleksandar

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Boban, M., Žulj, M., Peršić, V., Medved, I., Zekanović, D. i Včev, A. (2016). Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia. International Journal of Cardiology, 119., 277-281. doi: 10.1016/j.ijcard.2016.06.058

Boban, Marko, et al. "Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia." International Journal of Cardiology, vol. 119, 2016, str. 277-281. https://doi.org/10.1016/j.ijcard.2016.06.058

Boban, Marko, Marinko Žulj, Viktor Peršić, Igor Medved, Dražen Zekanović i Aleksandar Včev. "Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia." International Journal of Cardiology 119 (2016): 277-281. https://doi.org/10.1016/j.ijcard.2016.06.058

Boban, M., et al. (2016) 'Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia', International Journal of Cardiology, 119, str. 277-281. doi: 10.1016/j.ijcard.2016.06.058

Boban M, Žulj M, Peršić V, Medved I, Zekanović D, Včev A. Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia. International Journal of Cardiology [Internet]. 2016. [pristupljeno 24.12.2024.];119:277-281. doi: 10.1016/j.ijcard.2016.06.058

M. Boban, M. Žulj, V. Peršić, I. Medved, D. Zekanović i A. Včev, "Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia", International Journal of Cardiology, vol. 119, str. 277-281, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:522312. [Citirano: 24.12.2024.]

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Podaci o radu
Naslov (engleski)Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia
AutorMarko Boban
AutorMarinko Žulj
AutorViktor Peršić
AutorIgor Medved
AutorDražen Zekanović
AutorAleksandar Včev
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kirurgiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za rehabilitacijsku i sportsku medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Proton pump inhibitors (PPIs) are among the commonest drugs used nowadays. The aim of our study was to analyze prolonged utilization of proton pump inhibitors in medical therapy of patients with ischemic and valvular heart disease. Secondly, profile of utilization was scrutinized to patient characteristics and type of cardiovascular treatments. The study included consecutive patients scheduled for cardiovascular rehabilitation 2–6 months after index cardiovascular treatment. Two hundred ninety-four patients (n = 294/604 ; 48.7%) have been using proton pump inhibitor in their therapy after index cardiovascular treatment. Cardiovascular treatments were powerfully connected with utilization of PPIs ; surgery 5.77 (95%-confidence intervals [CI]: 4.05–8.22 ; p < 0.001) and PCI 0.15 (CI: 0.10– 0.22 ; p < 0.001). The odds for having proton pump inhibitor in their chronic therapy were increased for atrial fibrillation 1.87 (CI: 1.08–3.23 ; p = 0.025) and decreased for obesity 0.65 (CI: 0.45–0.96 ; p = 0.035) ; surviving myocardial infarction 0.49 (CI: 0.29–0.83 ; p = 0.035). Multinomial logistic regression controlled for existence of chronic renal disease found no significant association of renal dysfunction and PPI therapy. The existence of anemia was significantly increased in patients taking PPIs than controls ; 6.00 (CI: 3.85–9.33 ; p < 0.001). The use of PPI was also associated with worsening of metabolic profile, in part due to decreased utilization of ACE-inhibitors and statins. PPI consumption correlated with age of patients (Rho = 0.216 ; p < 0.001). High proportion of cardiovascular, particularly surgical patients with ischemic and valvular heart disease utilized proton pump inhibitor in prolonged courses. Prolonged courses of PPIs were connected with existence and worsening of red blood count indexes, older age, lesser weight of patients and underutilization of cardioprotective drugs.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Cardiology
Brojčani podacivol. 119, str. 277-281
p-ISSN0167-5273
DOIhttps://doi.org/10.1016/j.ijcard.2016.06.058
URN:NBNurn:nbn:hr:184:522312
Datum objave publikacije2016
URL dokumentahttp://bib.irb.hr/887686
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-03 13:41:24