prikaz prve stranice dokumenta Improvement of endothelial function by pitavastatin: a meta-analysis
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Scientific paper - Original scientific paper
Improvement of endothelial function by pitavastatin: a meta-analysis
Expert Opinion on Pharmacotherapy, 19 (2018), 3; 279-286. https://doi.org/10.1080/14656566.2018.1428560
Katsiki, Niki; Reiner, Željko; Tedeschi Reiner, Eugenia; Al-Rasadi, Khalid; Pirro, Matteo; Mikhailidis, Dimitri P.; Sahebkar, Amirhossein

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Katsiki, N., Reiner, Ž., Tedeschi Reiner, E., Al Rasadi, K., Pirro, M., Mikhailidis, D. P. & Sahebkar, A. (2018). Improvement of endothelial function by pitavastatin: a meta-analysis. Expert Opinion on Pharmacotherapy, 19. (3), 279-286. doi: 10.1080/14656566.2018.1428560

Katsiki, Niki, et al. "Improvement of endothelial function by pitavastatin: a meta-analysis." Expert Opinion on Pharmacotherapy, vol. 19, no. 3, 2018, pp. 279-286. https://doi.org/10.1080/14656566.2018.1428560

Katsiki, Niki, Željko Reiner, Eugenia Tedeschi Reiner, Khalid Al Rasadi, Matteo Pirro, Dimitri P. Mikhailidis and Amirhossein Sahebkar. "Improvement of endothelial function by pitavastatin: a meta-analysis." Expert Opinion on Pharmacotherapy 19, no. 3 (2018): 279-286. https://doi.org/10.1080/14656566.2018.1428560

Katsiki, N., et al. (2018) 'Improvement of endothelial function by pitavastatin: a meta-analysis', Expert Opinion on Pharmacotherapy, 19(3), pp. 279-286. doi: 10.1080/14656566.2018.1428560

Katsiki N, Reiner Ž, Tedeschi Reiner E, Al Rasadi K, Pirro M, Mikhailidis DP, and sur.. Improvement of endothelial function by pitavastatin: a meta-analysis. Expert Opinion on Pharmacotherapy [Internet]. 2018 [cited 2024 November 15];19(3):279-286. doi: 10.1080/14656566.2018.1428560

N. Katsiki, et al., "Improvement of endothelial function by pitavastatin: a meta-analysis", Expert Opinion on Pharmacotherapy, vol. 19, no. 3, pp. 279-286, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:221405. [Accessed: 15 November 2024]

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Metadata
Title (english)Improvement of endothelial function by pitavastatin: a meta-analysis
AuthorNiki Katsiki
AuthorŽeljko Reiner
MBZ: 65232
AuthorEugenia Tedeschi Reiner
MBZ: 152304
AuthorKhalid Al-Rasadi
AuthorMatteo Pirro
AuthorDimitri P. Mikhailidis
AuthorAmirhossein Sahebkar
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Objective. Dyslipidemia is commonly associated with endothelial dysfunction and increased cardiovascular risk. Pitavastatin has been shown to reduce total and low-density lipoprotein cholesterol, to increase high- density lipoprotein (HDL)-cholesterol and improve HDL function. Furthermore, several trials explored its effects on flow-mediated dilation (FMD), as an index of endothelial function. The authors evaluated the effect of pitavastatin therapy on FMD.Methods. The authors performed a systematic review and meta- analysis of all clinical trials exploring the impact of pitavastatin on FMD. The search included PubMed-Medline, Scopus, ISI Web of Knowledge and Google Scholar databases. Quantitative data synthesis was performed using a random-effects model, with weighted mean difference (WMD) and 95% confidence interval (CI) as summary statistics.Results. Six eligible studies comprising 7 treatment arms were selected for this meta-analysis. Overall, WMD was significant for the effect of pitavastatin on FMD (2.45%, 95% CI: 1.31, 3.60, p<0.001) and the effect size was robust in the leave-one-out sensitivity analysis.Conclusion. This meta-analysis of all available clinical trials revealed a significant increase of FMD induced by pitavastatin
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionAccepted version
Journal titleExpert Opinion on Pharmacotherapy
Numberingvol. 19, no. 3, pp. 279-286
p-ISSN1465-6566
DOIhttps://doi.org/10.1080/14656566.2018.1428560
URN:NBNurn:nbn:hr:184:221405
Publication2018
Document URLhttp://bib.irb.hr/1050328
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-22 17:31:32