prikaz prve stranice dokumenta FGF2 Enhances Odontoblast Differentiation by αSMA Progenitors In Vivo
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Scientific paper - Original scientific paper
FGF2 Enhances Odontoblast Differentiation by αSMA Progenitors In Vivo
Journal of Dental Research, 97 (2018), 10; 1170-1177. https://doi.org/10.1177/0022034518769827
Vidović-Zdrilić, Ivana; Vining, K.H.; Vijaykumar, A.; Kalajzić, I.; Mooney, D.J.; Mina, M.

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Vidović Zdrilić, I., Vining, K., Vijaykumar, A., Kalajzić, I., Mooney, D. & Mina, M. (2018). FGF2 Enhances Odontoblast Differentiation by αSMA Progenitors In Vivo. Journal of Dental Research, 97. (10), 1170-1177. doi: 10.1177/0022034518769827

Vidović Zdrilić, Ivana, et al. "FGF2 Enhances Odontoblast Differentiation by αSMA Progenitors In Vivo." Journal of Dental Research, vol. 97, no. 10, 2018, pp. 1170-1177. https://doi.org/10.1177/0022034518769827

Vidović Zdrilić, Ivana, K.H. Vining, A. Vijaykumar, I. Kalajzić, D.J. Mooney and M. Mina. "FGF2 Enhances Odontoblast Differentiation by αSMA Progenitors In Vivo." Journal of Dental Research 97, no. 10 (2018): 1170-1177. https://doi.org/10.1177/0022034518769827

Vidović Zdrilić, I., et al. (2018) 'FGF2 Enhances Odontoblast Differentiation by αSMA Progenitors In Vivo', Journal of Dental Research, 97(10), pp. 1170-1177. doi: 10.1177/0022034518769827

Vidović Zdrilić I, Vining K, Vijaykumar A, Kalajzić I, Mooney D, Mina M. FGF2 Enhances Odontoblast Differentiation by αSMA Progenitors In Vivo. Journal of Dental Research [Internet]. 2018 April 12 [cited 2025 February 13];97(10):1170-1177. doi: 10.1177/0022034518769827

I. Vidović Zdrilić, K. Vining, A. Vijaykumar, I. Kalajzić, D. Mooney and M. Mina, "FGF2 Enhances Odontoblast Differentiation by αSMA Progenitors In Vivo", Journal of Dental Research, vol. 97, no. 10, pp. 1170-1177, April 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:713083. [Accessed: 13 February 2025]

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Metadata
Title (english)FGF2 Enhances Odontoblast Differentiation by αSMA Progenitors In Vivo
AuthorIvana Vidović-Zdrilić
AuthorK.H. Vining
AuthorA. Vijaykumar
AuthorI. Kalajzić
AuthorD.J. Mooney
AuthorM. Mina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Endodontics and Restorative Dentistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Endodonics and Restorative Dentistry
Abstract (english)
The goal of this study was to examine the effects of early and limited exposure of perivascular cells expressing α (αSMA) to fibroblast growth factor 2 (FGF2) in vivo. We performed in vivo fate mapping by inducible Cre-loxP and experimental pulp injury in molars to induce reparative dentinogenesis. Our results demonstrate that early delivery of exogenous FGF2 to exposed pulp led to proliferative expansion of αSMA-tdTomato cells and their accelerated differentiation into odontoblasts. In vivo lineage-tracing experiments showed that the calcified bridge/reparative dentin in FGF2-treated pulps were lined with an increased number of Dspp odontoblasts and devoid of BSP osteoblasts. The increased number of odontoblasts derived from αSMA-tdTomato cells and the formation of reparative dentin devoid of osteoblasts provide in vivo evidence for the stimulatory effects of FGF signaling on odontoblast differentiation from early progenitors in dental pulp.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Dental Research
Numberingvol. 97, no. 10, pp. 1170-1177
p-ISSN0022-0345
e-ISSN1544-0591
DOIhttps://doi.org/10.1177/0022034518769827
URN:NBNurn:nbn:hr:184:713083
Publication2018-04-12
Document URLhttp://journals.sagepub.com/doi/10.1177/0022034518769827
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-02-21 13:36:24