prikaz prve stranice dokumenta Probe-Based Confocal Laser Endomicroscopy and Barrett’s Esophagus: Just a Scientific Toy or Significant Improvement in Diagnosis?
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Scientific paper - Original scientific paper
Probe-Based Confocal Laser Endomicroscopy and Barrett’s Esophagus: Just a Scientific Toy or Significant Improvement in Diagnosis?
Digestive Diseases, 40 (2022), 1; 97-105. https://doi.org/10.1159/000516257
Vranić, Luka; Nadarević, Tin; Štimac, Davor

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Vranić, L., Nadarević, T. & Štimac, D. (2022). Probe-Based Confocal Laser Endomicroscopy and Barrett’s Esophagus: Just a Scientific Toy or Significant Improvement in Diagnosis?. Digestive Diseases, 40. (1), 97-105. doi: 10.1159/000516257

Vranić, Luka, et al. "Probe-Based Confocal Laser Endomicroscopy and Barrett’s Esophagus: Just a Scientific Toy or Significant Improvement in Diagnosis?." Digestive Diseases, vol. 40, no. 1, 2022, pp. 97-105. https://doi.org/10.1159/000516257

Vranić, Luka, Tin Nadarević and Davor Štimac. "Probe-Based Confocal Laser Endomicroscopy and Barrett’s Esophagus: Just a Scientific Toy or Significant Improvement in Diagnosis?." Digestive Diseases 40, no. 1 (2022): 97-105. https://doi.org/10.1159/000516257

Vranić, L., Nadarević, T. and Štimac, D. (2022) 'Probe-Based Confocal Laser Endomicroscopy and Barrett’s Esophagus: Just a Scientific Toy or Significant Improvement in Diagnosis?', Digestive Diseases, 40(1), pp. 97-105. doi: 10.1159/000516257

Vranić L, Nadarević T, Štimac D. Probe-Based Confocal Laser Endomicroscopy and Barrett’s Esophagus: Just a Scientific Toy or Significant Improvement in Diagnosis?. Digestive Diseases [Internet]. 2022 April 01 [cited 2024 May 05];40(1):97-105. doi: 10.1159/000516257

L. Vranić, T. Nadarević and D. Štimac, "Probe-Based Confocal Laser Endomicroscopy and Barrett’s Esophagus: Just a Scientific Toy or Significant Improvement in Diagnosis?", Digestive Diseases, vol. 40, no. 1, pp. 97-105, April 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:533346. [Accessed: 05 May 2024]

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Metadata
Title (english)Probe-Based Confocal Laser Endomicroscopy and Barrett’s Esophagus: Just a Scientific Toy or Significant Improvement in Diagnosis?
AuthorLuka Vranić
AuthorTin Nadarević
AuthorDavor Štimac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: Barrett’s esophagus (BE) requires surveillance to identify potential neoplasia at an early stage. The standard surveillance regimen includes random 4-quadrant biopsies by Seattle protocol. Main limitations of random biopsies are high risk of sampling error, difficulties in histology interpretation, common inadequate classification of pathohistological changes, increased risk of bleeding, and time necessary to acquire the final diagnosis. Probe-based confocal laser endomicroscopy (pCLE) has emerged as a potential tool with an aim to overcome these obvious limitations. Summary: pCLE represents a real-time microscopic imaging method that offers evaluation of epithelial and subepithelial structures with 1,000-fold magnification. In theory, pCLE has potential to eliminate the need for biopsy in BE patients. The main advantages would be real-time diagnosis and decision-making, greater diagnostic accuracy, and evaluation of larger area compared to random biopsies. Clinical pCLE studies in the esophagus show high diagnostic accuracy, and its high negative predictive value offers high reliability and confidence to exclude dysplastic and neoplastic lesions. However, it still cannot replace histopathology due to lower positive predictive value and sensitivity. Key Messages: Despite promising results, its role in routine use in patients with BE remains questionable primarily due to lack of well-organized double-blind randomized trials.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDigestive Diseases
Numberingvol. 40, no. 1, pp. 97-105
p-ISSN0257-2753
e-ISSN1421-9875
DOIhttps://doi.org/10.1159/000516257
URN:NBNurn:nbn:hr:184:533346
Publication2022-04-01
Document URLhttps://www.karger.com/Article/FullText/516257
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-01-26 11:12:25