prikaz prve stranice dokumenta Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity
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Scientific paper - Original scientific paper
Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity
Oxidative Medicine and Cellular Longevity, 2020 (2020); 1-20. https://doi.org/10.1155/2020/6125638
Giacometti, Jasminka; Grubić Kezele, Tanja

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Giacometti, J. & Grubić Kezele, T. (2020). Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity. Oxidative Medicine and Cellular Longevity, 2020., 1-20. doi: 10.1155/2020/6125638

Giacometti, Jasminka and Tanja Grubić Kezele. "Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity." Oxidative Medicine and Cellular Longevity, vol. 2020, 2020, pp. 1-20. https://doi.org/10.1155/2020/6125638

Giacometti, Jasminka and Tanja Grubić Kezele. "Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity." Oxidative Medicine and Cellular Longevity 2020 (2020): 1-20. https://doi.org/10.1155/2020/6125638

Giacometti, J. and Grubić Kezele, T. (2020) 'Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity', Oxidative Medicine and Cellular Longevity, 2020, pp. 1-20. doi: 10.1155/2020/6125638

Giacometti J, Grubić Kezele T. Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity. Oxidative Medicine and Cellular Longevity [Internet]. 2020 July 31 [cited 2024 December 05];2020:1-20. doi: 10.1155/2020/6125638

J. Giacometti and T. Grubić Kezele, "Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity", Oxidative Medicine and Cellular Longevity, vol. 2020, pp. 1-20, July 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:763614. [Accessed: 05 December 2024]

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Title (english)Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity
AuthorJasminka Giacometti
AuthorTanja Grubić Kezele
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract (english)
Numerous evidences suggest that plant polyphenols may have therapeutic benefits in regulating oxidative stress and providing neuroprotection in many neurodegenerative diseases, including multiple sclerosis (MS). However, these mechanisms are not yet completely understood. In this study, we investigated the effect of olive leaf polyphenols on oxidative stress through oxidation marker level and activity (TBARS, SOD, and GPX) and their protein expression (SOD1, SOD2, and GPX1), as well as the protein expression of Sirtuin 1 (SIRT1) and microglia markers (Iba-1, CD206, and iNOS) and myelin integrity (proteolipid protein expression) in the brain of rats with induced experimental autoimmune encephalomyelitis (EAE) and subjected to olive leaf therapy. Experiments were performed in male EAE DA rats, which were randomly divided into 2 main groups: EAE groups treated with the therapy of olive leaf (EAE+TOL) and untreated EAE control groups. The EAE treated groups consumed olive leaf tea instead of drinking water ( ) from the beginning to the end of the experiment. In addition, olive leaf extract was injected intraperitoneally ( .) for the 10 continuous days and started on the 8 day after EAE induction. The clinical course was monitored in both groups until the 30 day after EAE induction. Our results demonstrated that TOL attenuated the clinical course of EAE; reduced the oxidative stress (by decreasing the concentration of MDA); upregulated antioxidant enzymes (SOD1, SOD2, and GPX1), SIRT1 (overall and microglial), and anti-inflammatory M2 microglia; downregulated proinflammatory M1 type; and preserved myelin integrity. These data support the idea that TOL may be an effective therapeutic approach for treating MS and other neurodegenerative diseases.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleOxidative Medicine and Cellular Longevity
Numberingvol. 2020, pp. 1-20, 6125638
p-ISSN1942-0900
e-ISSN1942-0994
DOIhttps://doi.org/10.1155/2020/6125638
URN:NBNurn:nbn:hr:184:763614
Publication2020-07-31
Document URLhttps://www.hindawi.com/journals/omcl/2020/6125638/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-09-17 12:07:02