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Scientific paper - Original scientific paper
LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME
Molecular and Experimental Biology in Medicine, 2 (2019), 1; 34-37. urn:nbn:hr:184:369803
Vraneković, Jadranka; Babić Božović, Ivana; Živković, Maja; Stanković, Aleksandra; Brajenović-Milić, Bojana

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Vraneković, J., Babić Božović, I., Živković, M., Stanković, A. & Brajenović Milić, B. (2019). LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME. Molecular and Experimental Biology in Medicine, 2. (1), 34-37. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:369803

Vraneković, Jadranka, et al. "LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME." Molecular and Experimental Biology in Medicine, vol. 2, no. 1, 2019, pp. 34-37. https://urn.nsk.hr/urn:nbn:hr:184:369803

Vraneković, Jadranka, Ivana Babić Božović, Maja Živković, Aleksandra Stanković and Bojana Brajenović Milić. "LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME." Molecular and Experimental Biology in Medicine 2, no. 1 (2019): 34-37. https://urn.nsk.hr/urn:nbn:hr:184:369803

Vraneković, J., et al. (2019) 'LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME', Molecular and Experimental Biology in Medicine, 2(1), pp. 34-37. Available at: https://urn.nsk.hr/urn:nbn:hr:184:369803 (Accessed 02 December 2024)

Vraneković J, Babić Božović I, Živković M, Stanković A, Brajenović Milić B. LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME. Molecular and Experimental Biology in Medicine [Internet]. 2019 [cited 2024 December 02];2(1):34-37. Available at: https://urn.nsk.hr/urn:nbn:hr:184:369803

J. Vraneković, I. Babić Božović, M. Živković, A. Stanković and B. Brajenović Milić, "LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME", Molecular and Experimental Biology in Medicine, vol. 2, no. 1, pp. 34-37, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:369803. [Accessed: 02 December 2024]

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Metadata
Title (english)LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME
AuthorJadranka Vraneković
AuthorIvana Babić Božović
AuthorMaja Živković
AuthorAleksandra Stanković
AuthorBojana Brajenović-Milić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
DNA methylation is a key epigenetic mechanism that plays a significant role in regulating gene activity during cardiac development. Congenital heart defects (CHD) are one of the most common abnormalities occurring in 40% -60% of cases with Down syndrome (DS). The main aim of this study was to establish the association of long interspersed nucleotide element-1 (LINE-1) DNA methylation in children with DS and the presence of CHD. The LINE-1 DNA methylation was investigated in peripheral blood lymphocytes on a sample of 42 people with DS by quantification of LINE-1 methylation using the MethyLight method. No significant differences in global DNA methylation were found according to the presence of CHD (P=1.000), but values of LINE-1 DNA methylation were significantly influenced by gender (R2=19.1%; P=0.025). Significant probability of 19.1% was found in women with DS who had lower LINE-1 DNA methylation values than DS male. Gender was a statistically significant predictor of LINE-1 DNA methylation, although the difference was not statistically significant, female subjects had lower LINE-1 DNA methylation values (P=0.068). Further research will clarify the role of lower LINE-1 DNA methylation in the formation of CHD among DS females.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMolecular and Experimental Biology in Medicine
Numberingvol. 2, no. 1, pp. 34-37
p-ISSN2584-671X
URN:NBNurn:nbn:hr:184:369803
Publication2019
Document URLhttps://hrcak.srce.hr/224342
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2019-11-05 12:50:02