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LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME
Molecular and Experimental Biology in Medicine, 2 (2019), 1; 34-37. urn:nbn:hr:184:369803
Vraneković, Jadranka; Babić Božović, Ivana; Živković, Maja; Stanković, Aleksandra; Brajenović-Milić, Bojana

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Vraneković, J., Babić Božović, I., Živković, M., Stanković, A. i Brajenović Milić, B. (2019). LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME. Molecular and Experimental Biology in Medicine, 2. (1), 34-37. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:369803

Vraneković, Jadranka, et al. "LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME." Molecular and Experimental Biology in Medicine, vol. 2, br. 1, 2019, str. 34-37. https://urn.nsk.hr/urn:nbn:hr:184:369803

Vraneković, Jadranka, Ivana Babić Božović, Maja Živković, Aleksandra Stanković i Bojana Brajenović Milić. "LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME." Molecular and Experimental Biology in Medicine 2, br. 1 (2019): 34-37. https://urn.nsk.hr/urn:nbn:hr:184:369803

Vraneković, J., et al. (2019) 'LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME', Molecular and Experimental Biology in Medicine, 2(1), str. 34-37. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:369803 (Datum pristupa: 27.12.2024.)

Vraneković J, Babić Božović I, Živković M, Stanković A, Brajenović Milić B. LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME. Molecular and Experimental Biology in Medicine [Internet]. 2019. [pristupljeno 27.12.2024.];2(1):34-37. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:369803

J. Vraneković, I. Babić Božović, M. Živković, A. Stanković i B. Brajenović Milić, "LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME", Molecular and Experimental Biology in Medicine, vol. 2, br. 1, str. 34-37, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:369803. [Citirano: 27.12.2024.]

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Naslov (engleski)LINE-1 DNA METHYLATION AND CONGENITAL HEART DEFECTS IN DOWN SYNDROME
AutorJadranka Vraneković
AutorIvana Babić Božović
AutorMaja Živković
AutorAleksandra Stanković
AutorBojana Brajenović-Milić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
DNA methylation is a key epigenetic mechanism that plays a significant role in regulating gene activity during cardiac development. Congenital heart defects (CHD) are one of the most common abnormalities occurring in 40% -60% of cases with Down syndrome (DS). The main aim of this study was to establish the association of long interspersed nucleotide element-1 (LINE-1) DNA methylation in children with DS and the presence of CHD. The LINE-1 DNA methylation was investigated in peripheral blood lymphocytes on a sample of 42 people with DS by quantification of LINE-1 methylation using the MethyLight method. No significant differences in global DNA methylation were found according to the presence of CHD (P=1.000), but values of LINE-1 DNA methylation were significantly influenced by gender (R2=19.1%; P=0.025). Significant probability of 19.1% was found in women with DS who had lower LINE-1 DNA methylation values than DS male. Gender was a statistically significant predictor of LINE-1 DNA methylation, although the difference was not statistically significant, female subjects had lower LINE-1 DNA methylation values (P=0.068). Further research will clarify the role of lower LINE-1 DNA methylation in the formation of CHD among DS females.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMolecular and Experimental Biology in Medicine
Brojčani podacivol. 2, br. 1, str. 34-37
p-ISSN2584-671X
URN:NBNurn:nbn:hr:184:369803
Datum objave publikacije2019
URL dokumentahttps://hrcak.srce.hr/224342
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Bez prerada 4.0 međunarodna (CC BY-ND 4.0)
Datum i vrijeme pohrane2019-11-05 12:50:02