prikaz prve stranice dokumenta Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis
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Scientific paper - Original scientific paper
Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis
Serbian Journal of Experimental and Clinical Research, 15 (2014), 4; 183-190. https://doi.org/10.2478/sjecr-2014-0023
Milovanović, Jelena; Arsenijević, Aleksandar; Stojanović, Bojana; Milovanović, Marija; Jonjić, Stipan; Popović, Branka; Arsenijević, Nebojša; Lukić, Miodrag L.

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Milovanović, J., Arsenijević, A., Stojanović, B., Milovanović, M., Jonjić, S., Popović, B. ... Lukić, M. L. (2014). Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis. Serbian Journal of Experimental and Clinical Research, 15. (4), 183-190. doi: 10.2478/sjecr-2014-0023

Milovanović, Jelena, et al. "Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis." Serbian Journal of Experimental and Clinical Research, vol. 15, no. 4, 2014, pp. 183-190. https://doi.org/10.2478/sjecr-2014-0023

Milovanović, Jelena, Aleksandar Arsenijević, Bojana Stojanović, Marija Milovanović, Stipan Jonjić, Branka Popović, Nebojša Arsenijević and Miodrag L. Lukić. "Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis." Serbian Journal of Experimental and Clinical Research 15, no. 4 (2014): 183-190. https://doi.org/10.2478/sjecr-2014-0023

Milovanović, J., et al. (2014) 'Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis', Serbian Journal of Experimental and Clinical Research, 15(4), pp. 183-190. doi: 10.2478/sjecr-2014-0023

Milovanović J, Arsenijević A, Stojanović B, Milovanović M, Jonjić S, Popović B, and sur.. Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis. Serbian Journal of Experimental and Clinical Research [Internet]. 2014 December 01 [cited 2024 November 18];15(4):183-190. doi: 10.2478/sjecr-2014-0023

J. Milovanović, et al., "Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis", Serbian Journal of Experimental and Clinical Research, vol. 15, no. 4, pp. 183-190, December 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:377225. [Accessed: 18 November 2024]

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Metadata
Title (english)Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis
AuthorJelena Milovanović
AuthorAleksandar Arsenijević
AuthorBojana Stojanović
AuthorMarija Milovanović
AuthorStipan Jonjić
AuthorBranka Popović
AuthorNebojša Arsenijević
AuthorMiodrag L. Lukić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
ABSTRACT Viral infection has been identified as the most likely environmental trigger of multiple sclerosis (MS). There are conflicting data regarding the role of cytomegalovirus (CMV) in MS pathogenesis. We utilised experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice and murine cytomegalovirus (MCMV), the murine homolog of CMV, to examine the mechanism by which viral infection enhances autoimmune neuroinflammation. Mice subjected to latent neonatal MCMV infection developed the typical characteristics of EAE. Similar to MS, the MCMV-infected EAE-induced mice developed infiltrates in the central nervous system (CNS) composed of similar percentages of CD4+ and CD8+ T cells. The influx of both Th 1 and Th 17 cells into the CNS of MCMV- infected EAE-induced mice was observed. Interestingly, the development of autoimmune neuroinflammation after latent MCMV infection was accompanied by a significant influx of Tc17 cells (CD8+IL-17+ and CD8+RoRγt+) but not Tc1, cells. Our results suggest that latent MCMV infection affects the development of inflammatory lymphocytes that exhibit encephalitogenic potential, thereby mediating increased CNS pathology following EAE induction, and that CMV represents a possible environmental factor in the pathogenesis of MS and other autoimmune diseases
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleSerbian Journal of Experimental and Clinical Research
Numberingvol. 15, no. 4, pp. 183-190
p-ISSN1820-8665
e-ISSN2335-075X
DOIhttps://doi.org/10.2478/sjecr-2014-0023
URN:NBNurn:nbn:hr:184:377225
Publication2014-12-01
Document URLhttps://content.sciendo.com/view/journals/sjecr/15/4/article-p183.xml
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2019-05-15 16:19:03