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Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis
Serbian Journal of Experimental and Clinical Research, 15 (2014), 4; 183-190. https://doi.org/10.2478/sjecr-2014-0023
Milovanović, Jelena; Arsenijević, Aleksandar; Stojanović, Bojana; Milovanović, Marija; Jonjić, Stipan; Popović, Branka; Arsenijević, Nebojša; Lukić, Miodrag L.

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Milovanović, J., Arsenijević, A., Stojanović, B., Milovanović, M., Jonjić, S., Popović, B. ... Lukić, M. L. (2014). Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis. Serbian Journal of Experimental and Clinical Research, 15. (4), 183-190. doi: 10.2478/sjecr-2014-0023

Milovanović, Jelena, et al. "Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis." Serbian Journal of Experimental and Clinical Research, vol. 15, br. 4, 2014, str. 183-190. https://doi.org/10.2478/sjecr-2014-0023

Milovanović, Jelena, Aleksandar Arsenijević, Bojana Stojanović, Marija Milovanović, Stipan Jonjić, Branka Popović, Nebojša Arsenijević i Miodrag L. Lukić. "Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis." Serbian Journal of Experimental and Clinical Research 15, br. 4 (2014): 183-190. https://doi.org/10.2478/sjecr-2014-0023

Milovanović, J., et al. (2014) 'Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis', Serbian Journal of Experimental and Clinical Research, 15(4), str. 183-190. doi: 10.2478/sjecr-2014-0023

Milovanović J, Arsenijević A, Stojanović B, Milovanović M, Jonjić S, Popović B, i sur.. Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis. Serbian Journal of Experimental and Clinical Research [Internet]. 01.12.2014. [pristupljeno 19.11.2024.];15(4):183-190. doi: 10.2478/sjecr-2014-0023

J. Milovanović, et al., "Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis", Serbian Journal of Experimental and Clinical Research, vol. 15, br. 4, str. 183-190, Prosinac 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:377225. [Citirano: 19.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:377225
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Naslov (engleski)Latent Murine Cytomegalovirus Infection Contributes to EAE Pathogenesis
AutorJelena Milovanović
AutorAleksandar Arsenijević
AutorBojana Stojanović
AutorMarija Milovanović
AutorStipan Jonjić
AutorBranka Popović
AutorNebojša Arsenijević
AutorMiodrag L. Lukić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
ABSTRACT Viral infection has been identified as the most likely environmental trigger of multiple sclerosis (MS). There are conflicting data regarding the role of cytomegalovirus (CMV) in MS pathogenesis. We utilised experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice and murine cytomegalovirus (MCMV), the murine homolog of CMV, to examine the mechanism by which viral infection enhances autoimmune neuroinflammation. Mice subjected to latent neonatal MCMV infection developed the typical characteristics of EAE. Similar to MS, the MCMV-infected EAE-induced mice developed infiltrates in the central nervous system (CNS) composed of similar percentages of CD4+ and CD8+ T cells. The influx of both Th 1 and Th 17 cells into the CNS of MCMV- infected EAE-induced mice was observed. Interestingly, the development of autoimmune neuroinflammation after latent MCMV infection was accompanied by a significant influx of Tc17 cells (CD8+IL-17+ and CD8+RoRγt+) but not Tc1, cells. Our results suggest that latent MCMV infection affects the development of inflammatory lymphocytes that exhibit encephalitogenic potential, thereby mediating increased CNS pathology following EAE induction, and that CMV represents a possible environmental factor in the pathogenesis of MS and other autoimmune diseases
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaSerbian Journal of Experimental and Clinical Research
Brojčani podacivol. 15, br. 4, str. 183-190
p-ISSN1820-8665
e-ISSN2335-075X
DOIhttps://doi.org/10.2478/sjecr-2014-0023
URN:NBNurn:nbn:hr:184:377225
Datum objave publikacije2014-12-01
URL dokumentahttps://content.sciendo.com/view/journals/sjecr/15/4/article-p183.xml
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2019-05-15 16:19:03