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Scientific paper - Original scientific paper
ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA
Psychiatria Danubina, 20. (2008), 4.; 456-460. urn:nbn:hr:184:094363
Mršić Pelčić, Jasenka; Pelčić, Goran; Vitezić, Dinko; Ljubičić, Đulijano; Župan, Gordana; Simonić, Ante

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Mršić Pelčić, J., Pelčić, G., Vitezić, D., Ljubičić, Đ., Župan, G. & Simonić, A. (2008). ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA. Psychiatria Danubina, 20.. (4.), 456-460. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:094363

Mršić Pelčić, Jasenka, et al. "ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA." Psychiatria Danubina, vol. 20., no. 4., 2008, pp. 456-460. https://urn.nsk.hr/urn:nbn:hr:184:094363

Mršić Pelčić, Jasenka, Goran Pelčić, Dinko Vitezić, Đulijano Ljubičić, Gordana Župan and Ante Simonić. "ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA." Psychiatria Danubina 20., no. 4. (2008): 456-460. https://urn.nsk.hr/urn:nbn:hr:184:094363

Mršić Pelčić, J., et al. (2008) 'ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA', Psychiatria Danubina, 20.(4.), pp. 456-460. Available at: https://urn.nsk.hr/urn:nbn:hr:184:094363 (Accessed 05 December 2024)

Mršić Pelčić J, Pelčić G, Vitezić D, Ljubičić Đ, Župan G, Simonić A. ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA. Psychiatria Danubina [Internet]. 2008 November 06 [cited 2024 December 05];20.(4.):456-460. Available at: https://urn.nsk.hr/urn:nbn:hr:184:094363

J. Mršić Pelčić, G. Pelčić, D. Vitezić, Đ. Ljubičić, G. Župan and A. Simonić, "ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA", Psychiatria Danubina, vol. 20., no. 4., pp. 456-460, November 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:094363. [Accessed: 05 December 2024]

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Title (english)ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA
AuthorJasenka Mršić Pelčić
AuthorGoran Pelčić
AuthorDinko Vitezić
AuthorĐulijano Ljubičić
AuthorGordana Župan
AuthorAnte Simonić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pharmacology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Ophthalmology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
SUMMARY Objectives: To determine the influence of global cerebral ischemia on the activation of extracellular-regulated kinases (ERK) and c-Jun N terminal kinases (JNK) in optic nerves of rats exposed to different reperfusion periods. Materials and methods: Transient global cerebral ischemia (20-min duration) was induced by the four-vessel occlusion method. After different reperfusion periods (5 and 10 min; 1; 6 and 12 h after ischemia), optic nerves were extracted and ERK and JNK activation signals were determined by Western immunoblot analyses. Results: The activation signals of ERK and JNK were detected within first 10 min of reperfusion, but striking activation for both enzymes was found 1 h after ischemia. After a transient decrease, the activation of ERK returned to peak level after 12 h of reperfusion in the second wave of kinase activation. In that period, a slight increase of JNK activation was registered. Conclusion: Our results demonstrated for the first time that ERK and JNK were activated in rat optic nerves during early and later periods of reperfusion, suggesting their potential active role in the response of cerebral white matter tissue to ischemic injury.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePsychiatria Danubina
Numberingvol. 20., no. 4., pp. 456-460
p-ISSN0353-5053
URN:NBNurn:nbn:hr:184:094363
Publication2008-11-06
Document URLhttps://hrcak.srce.hr/29072
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2018-12-04 23:22:34