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ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA
Psychiatria Danubina, 20. (2008), 4.; 456-460. urn:nbn:hr:184:094363
Mršić Pelčić, Jasenka; Pelčić, Goran; Vitezić, Dinko; Ljubičić, Đulijano; Župan, Gordana; Simonić, Ante

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Mršić Pelčić, J., Pelčić, G., Vitezić, D., Ljubičić, Đ., Župan, G. i Simonić, A. (2008). ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA. Psychiatria Danubina, 20.. (4.), 456-460. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:094363

Mršić Pelčić, Jasenka, et al. "ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA." Psychiatria Danubina, vol. 20., br. 4., 2008, str. 456-460. https://urn.nsk.hr/urn:nbn:hr:184:094363

Mršić Pelčić, Jasenka, Goran Pelčić, Dinko Vitezić, Đulijano Ljubičić, Gordana Župan i Ante Simonić. "ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA." Psychiatria Danubina 20., br. 4. (2008): 456-460. https://urn.nsk.hr/urn:nbn:hr:184:094363

Mršić Pelčić, J., et al. (2008) 'ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA', Psychiatria Danubina, 20.(4.), str. 456-460. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:094363 (Datum pristupa: 04.12.2024.)

Mršić Pelčić J, Pelčić G, Vitezić D, Ljubičić Đ, Župan G, Simonić A. ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA. Psychiatria Danubina [Internet]. 06.11.2008. [pristupljeno 04.12.2024.];20.(4.):456-460. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:094363

J. Mršić Pelčić, G. Pelčić, D. Vitezić, Đ. Ljubičić, G. Župan i A. Simonić, "ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA", Psychiatria Danubina, vol. 20., br. 4., str. 456-460, Studeni 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:094363. [Citirano: 04.12.2024.]

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Podaci o radu
Naslov (engleski)ACTIVATION OF ERK AND JNK MAP KINASES IN OPTIC NERVES OF RATS EXPOSED TO GLOBAL CEREBRAL ISCHEMIA
AutorJasenka Mršić Pelčić
AutorGoran Pelčić
AutorDinko Vitezić
AutorĐulijano Ljubičić
AutorGordana Župan
AutorAnte Simonić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za farmakologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za oftalmologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za psihijatriju i psihološku medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
SUMMARY Objectives: To determine the influence of global cerebral ischemia on the activation of extracellular-regulated kinases (ERK) and c-Jun N terminal kinases (JNK) in optic nerves of rats exposed to different reperfusion periods. Materials and methods: Transient global cerebral ischemia (20-min duration) was induced by the four-vessel occlusion method. After different reperfusion periods (5 and 10 min; 1; 6 and 12 h after ischemia), optic nerves were extracted and ERK and JNK activation signals were determined by Western immunoblot analyses. Results: The activation signals of ERK and JNK were detected within first 10 min of reperfusion, but striking activation for both enzymes was found 1 h after ischemia. After a transient decrease, the activation of ERK returned to peak level after 12 h of reperfusion in the second wave of kinase activation. In that period, a slight increase of JNK activation was registered. Conclusion: Our results demonstrated for the first time that ERK and JNK were activated in rat optic nerves during early and later periods of reperfusion, suggesting their potential active role in the response of cerebral white matter tissue to ischemic injury.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPsychiatria Danubina
Brojčani podacivol. 20., br. 4., str. 456-460
p-ISSN0353-5053
URN:NBNurn:nbn:hr:184:094363
Datum objave publikacije2008-11-06
URL dokumentahttps://hrcak.srce.hr/29072
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2018-12-04 23:22:34