prikaz prve stranice dokumenta NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice
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Scientific paper - Original scientific paper
NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice
European Journal of Immunology, 47 (2017), 7; 1123-1135. https://doi.org/10.1002/eji.201646805
Kavazović, Inga; Lenartić, Maja; Jelenčić, Vedrana; Jurković, Slaven; Lemmermann, Niels A.W.; Jonjić, Stipan; Polić, Bojan; Wensveen, Felix M.

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Kavazović, I., Lenartić, M., Jelenčić, V., Jurković, S., Lemmermann, N. A., Jonjić, S. ... Wensveen, F. M. (2017). NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice. European Journal of Immunology, 47. (7), 1123-1135. doi: 10.1002/eji.201646805

Kavazović, Inga, et al. "NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice." European Journal of Immunology, vol. 47, no. 7, 2017, pp. 1123-1135. https://doi.org/10.1002/eji.201646805

Kavazović, Inga, Maja Lenartić, Vedrana Jelenčić, Slaven Jurković, Niels A.W. Lemmermann, Stipan Jonjić, Bojan Polić and Felix M. Wensveen. "NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice." European Journal of Immunology 47, no. 7 (2017): 1123-1135. https://doi.org/10.1002/eji.201646805

Kavazović, I., et al. (2017) 'NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice', European Journal of Immunology, 47(7), pp. 1123-1135. doi: 10.1002/eji.201646805

Kavazović I, Lenartić M, Jelenčić V, Jurković S, Lemmermann NA, Jonjić S, and sur.. NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice. European Journal of Immunology [Internet]. 2017 July [cited 2024 November 16];47(7):1123-1135. doi: 10.1002/eji.201646805

I. Kavazović, et al., "NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice", European Journal of Immunology, vol. 47, no. 7, pp. 1123-1135, July 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:922259. [Accessed: 16 November 2024]

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Metadata
Title (english)NKG2D stimulation of CD8 T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice
AuthorInga Kavazović
AuthorMaja Lenartić
AuthorVedrana Jelenčić
AuthorSlaven Jurković
AuthorNiels A.W. Lemmermann
AuthorStipan Jonjić
AuthorBojan Polić
AuthorFelix M. Wensveen
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Natural killer group 2 member D (NKG2D) is an activating receptor that is expressed on most cytotoxic cells of the immune system, including NK cells, γδ, and CD8+ T cells. It is still a matter of debate whether and how NKG2D mediates priming of CD8+ T cells in vivo, due to a lack of studies where NKG2D is eliminated exclusively in these cells. Here, we studied the impact of NKG2D on effector CD8+ T-cell formation. NKG2D deficiency that is restricted to murine CD8+ T cells did not impair antigen-specific T-cell expansion following mouse CMV and lymphocytic choriomeningitis virus infection, but reduced their capacity to produce cytokines. Upon infection, conventional dendritic cells induce NKG2D ligands, which drive cytokine production on CD8+ T cells via the Dap10 signaling pathway. T-cell development, homing, and proliferation were not affected by NKG2D deficiency and cytotoxicity was only impaired when strong T-cell receptor (TCR) stimuli were used. Transfer of antigen-specific CD8+ T cells demonstrated that NKG2D deficiency attenuated their capacity to reduce viral loads. The inability of NKG2D-deficient cells to produce cytokines could be overcome with injection of IL-15 superagonist during priming. In summary, our data show that NKG2D has a nonredundant role in priming of CD8+ T cells to produce antiviral cytokines.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEuropean Journal of Immunology
Numberingvol. 47, no. 7, pp. 1123-1135
p-ISSN0014-2980
DOIhttps://doi.org/10.1002/eji.201646805
URN:NBNurn:nbn:hr:184:922259
Publication2017-07
Publication2017-05-02
ProjectNumber: 274995
Title (croatian): Memory Control; The role of NKG2D and the T-cell receptor in memory T cell biology.
Acronym: NKG2D IN T-CELLS
Jurisdiction: eu
Funding stream: FP7
Document URLhttp://doi.wiley.com/10.1002/eji.201646805
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-11-30 08:02:40