Participation of endogenous tumour necrosis factor   in host resistance to cytomegalovirus infection

Pavić, Ivica; Polić, Bojan; Crnković, Irena; Lučin, Pero; Jonjić, Stipan; Koszinowski, U. H.

doi:10.1099/0022-1317-74-10-2215

prikaz prve stranice dokumenta Participation of endogenous tumour necrosis factor in host resistance to cytomegalovirus infection

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Scientific paper - Original scientific paper

Participation of endogenous tumour necrosis factor in host resistance to cytomegalovirus infection

Journal of General Virology, 74 (1993), 10; 2215-2223. https://doi.org/10.1099/0022-1317-74-10-2215

Pavić, Ivica; Polić, Bojan; Crnković, Irena; Lučin, Pero; Jonjić, Stipan; Koszinowski, U. H.

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APA 6th Edition

Pavić, I., Polić, B., Crnković, I., Lučin, P., Jonjić, S. & Koszinowski, U. H. (1993). Participation of endogenous tumour necrosis factor in host resistance to cytomegalovirus infection. Journal of General Virology, 74. (10), 2215-2223. doi: 10.1099/0022-1317-74-10-2215

MLA 8th Edition

Pavić, Ivica, et al. "Participation of endogenous tumour necrosis factor in host resistance to cytomegalovirus infection." Journal of General Virology, vol. 74, no. 10, 1993, pp. 2215-2223. https://doi.org/10.1099/0022-1317-74-10-2215

Chicago 17th Edition

Pavić, Ivica, Bojan Polić, Irena Crnković, Pero Lučin, Stipan Jonjić and U. H. Koszinowski. "Participation of endogenous tumour necrosis factor in host resistance to cytomegalovirus infection." Journal of General Virology 74, no. 10 (1993): 2215-2223. https://doi.org/10.1099/0022-1317-74-10-2215

Harvard

Pavić, I., et al. (1993) 'Participation of endogenous tumour necrosis factor in host resistance to cytomegalovirus infection', Journal of General Virology, 74(10), pp. 2215-2223. doi: 10.1099/0022-1317-74-10-2215

Vancouver

Pavić I, Polić B, Crnković I, Lučin P, Jonjić S, Koszinowski UH. Participation of endogenous tumour necrosis factor in host resistance to cytomegalovirus infection. Journal of General Virology [Internet]. 1993 October 01 [cited 2024 December 03];74(10):2215-2223. doi: 10.1099/0022-1317-74-10-2215

IEEE

I. Pavić, B. Polić, I. Crnković, P. Lučin, S. Jonjić and U. H. Koszinowski, "Participation of endogenous tumour necrosis factor in host resistance to cytomegalovirus infection", Journal of General Virology, vol. 74, no. 10, pp. 2215-2223, October 1993. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:611848. [Accessed: 03 December 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:611848

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Metadata

Title (english)	Participation of endogenous tumour necrosis factor in host resistance to cytomegalovirus infection
Author	Ivica Pavić
Author	Bojan Polić
Author	Irena Crnković
Author	Pero Lučin
Author	Stipan Jonjić
Author	U. H. Koszinowski
Author's institution	University of Rijeka Faculty of Medicine (Department of Physiology, Immunology and Pathophxsiology)
Author's institution	University of Rijeka Faculty of Medicine (Department of Histology and Embryology)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences
Abstract (english)	Interferon gamma (IFN gamma) represents an essential cytokine involved in murine cytomegalovirus (MCMV) clearance from the salivary gland and the control of horizontal transmission. Because IFN gamma cannot be responsible for all cytokine effects during recovery from MCMV infection we have now tested the potential participation of tumour necrosis factor alpha (TNF alpha) in the antiviral defence. Neutralization of endogenous TNF alpha abolished the antiviral activity of CD4 T cells in immunocompetent as well as in CD8 subset-deficient mice. These data suggest that the antiviral effect of the CD4 subset requires the presence of at least two cytokines, namely IFN gamma and TNF alpha. Depletion of endogenous TNF alpha in adoptive cell transfer recipients diminished the antiviral function of CD8 T lymphocytes suggesting that TNF alpha also participates in CD8 T cell effector functions. Furthermore, endogenous cytokines were found to be required for survival after infection with lethal doses of MCMV, whereas immunotherapy with recombinant TNF alpha and IFN gamma could not limit virus replication in vivo. The results suggest that, similar to IFN gamma, TNF alpha is an integral part of the protective mechanisms involved in cytomegalovirus clearance.
Keywords (croatian)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review - international
Publication version	Published version
Journal title	Journal of General Virology
Numbering	vol. 74, no. 10, pp. 2215-2223
p-ISSN	0022-1317
e-ISSN	1465-2099
DOI	https://doi.org/10.1099/0022-1317-74-10-2215
URN:NBN	urn:nbn:hr:184:611848
Publication	1993-10-01
Document URL	http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-74-10-2215
Type of resource	Text
Access conditions	Open access
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Created on	2018-11-29 22:10:14