prikaz prve stranice dokumenta Ventricular diastolic dimension over maximal myocardial thickness is robust landmark of systolic impairment in patients with hypertrophic cardiomyopathy
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Scientific paper - Original scientific paper
Ventricular diastolic dimension over maximal myocardial thickness is robust landmark of systolic impairment in patients with hypertrophic cardiomyopathy
Medical Science Monitor, 24 (2018); 1880-1886. https://doi.org/10.12659/MSM.906111
Boban, Marko; Pesa, Vladimir; Antić Kauzlarić, Helena; Brusich, Sandro; Rotim, Ante; Madžar, Tomislav; Žulj, Marinko; Včev, Aleksandar

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Boban, M., Pesa, V., Antić Kauzlarić, H., Brusich, S., Rotim, A., Madžar, T. ... Včev, A. (2018). Ventricular diastolic dimension over maximal myocardial thickness is robust landmark of systolic impairment in patients with hypertrophic cardiomyopathy. Medical Science Monitor, 24., 1880-1886. doi: 10.12659/MSM.906111

Boban, Marko, et al. "Ventricular diastolic dimension over maximal myocardial thickness is robust landmark of systolic impairment in patients with hypertrophic cardiomyopathy." Medical Science Monitor, vol. 24, 2018, pp. 1880-1886. https://doi.org/10.12659/MSM.906111

Boban, Marko, Vladimir Pesa, Helena Antić Kauzlarić, Sandro Brusich, Ante Rotim, Tomislav Madžar, Marinko Žulj and Aleksandar Včev. "Ventricular diastolic dimension over maximal myocardial thickness is robust landmark of systolic impairment in patients with hypertrophic cardiomyopathy." Medical Science Monitor 24 (2018): 1880-1886. https://doi.org/10.12659/MSM.906111

Boban, M., et al. (2018) 'Ventricular diastolic dimension over maximal myocardial thickness is robust landmark of systolic impairment in patients with hypertrophic cardiomyopathy', Medical Science Monitor, 24, pp. 1880-1886. doi: 10.12659/MSM.906111

Boban M, Pesa V, Antić Kauzlarić H, Brusich S, Rotim A, Madžar T, and sur.. Ventricular diastolic dimension over maximal myocardial thickness is robust landmark of systolic impairment in patients with hypertrophic cardiomyopathy. Medical Science Monitor [Internet]. 2018 March [cited 2024 December 23];24:1880-1886. doi: 10.12659/MSM.906111

M. Boban, et al., "Ventricular diastolic dimension over maximal myocardial thickness is robust landmark of systolic impairment in patients with hypertrophic cardiomyopathy", Medical Science Monitor, vol. 24, pp. 1880-1886, March 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:881955. [Accessed: 23 December 2024]

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Metadata
Title (english)Ventricular diastolic dimension over maximal myocardial thickness is robust landmark of systolic impairment in patients with hypertrophic cardiomyopathy
AuthorMarko Boban
AuthorVladimir Pesa
AuthorHelena Antić Kauzlarić
AuthorSandro Brusich
AuthorAnte Rotim
AuthorTomislav Madžar
AuthorMarinko Žulj
AuthorAleksandar Včev
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
BACKGROUND The effects of focal hypertrophy on geometry of the left ventricle and systolic function have not been studied in patients with hypertrophic cardiomyopathy (HCM), despite the fact that the former is the most prominent disease characteristic. The aim of our study was to analyze systolic function over ventricle geometry, generating a functional index made from left ventricle end diastolic dimension (LVEDD) divided by end diastolic thickness of the region with maximal extent of hypertrophy and interventricular septum. MATERIAL AND METHODS Our hospital database of cardiac magnetic resonance was screened for HCM. Geometric functional index (GFI) was calculated for LVEDD over maximal end diastolic thickness (MaxEDT) giving GFI-M, while LVEDD over interventricular septum was expressed as GFI-I. There were 55 consecutive patients with HCM. RESULTS There were 43 males (78.2%) and 12 females (21.8%). The mean age was 52.3±16.7 years (range: 15.5-76.4 years). A significant difference of GFI was found for preserved versus impaired systolic function of the left ventricle (preserved systolic function); GFI-M 2.28±0.60 versus 3.66±0.50 (p<0.001), and GFI-I 2.75±0.88 versus 3.81±0.87 (p<0.001), respectively. Diagnostic value was tested using receiver operating curve (ROC) analyzes, with GFI-M area under curve (AUC)=0.959 (95% CI: 0.868-0.994); (p<0.001) and GFI-I-AUC=0.847 (0.724-0.930); (p<0.001). GFI-M was superior to GFI-I for appraisal of left ventricle systolic dysfunction in HCM; ΔAUC=0.112 (0.018-0.207); (p=0.020). CONCLUSIONS GFI is a simple tool, with high sensitivity and specificity for detecting impairment of systolic function in patients with HCM. Further studies would be necessary to investigate its clinical and prognostic impacts, as well as reproducibility with prospective validation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical Science Monitor
Numberingvol. 24, pp. 1880-1886
e-ISSN1643-3750
DOIhttps://doi.org/10.12659/MSM.906111
URN:NBNurn:nbn:hr:184:881955
Publication2018-03
Document URLhttps://www.medscimonit.com/download/index/idArt/906111
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-04-18 14:36:22