prikaz prve stranice dokumenta Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
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Scientific paper - Original scientific paper
Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
PLoS ONE, 13 (2018), 1; 1-7. https://doi.org/10.1371/journal.pone.0190601
Lavtar, Polona; Rudolf, Gorazd; Maver, Ales; Hodžić, Alenka; Čizmarević, Nada Starčević; Živkovic, Maja; Jazbec, Sasa Sega; Ketis, Zalika Klemenc; Kapović, Miljenko; Dinčić, Evica; Raičević, Ranko; Sepčić, Juraj; Lovrečić, Luca; Stanković, Aleksandra; Ristić, Smiljana; Peterlin, Borut More authors...

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Lavtar, P., Rudolf, G., Maver, A., Hodžić, A., Čizmarević, N. S., Živkovic, M. ... Peterlin, B. (2018). Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis. PLoS ONE, 13. (1), 1-7. doi: 10.1371/journal.pone.0190601

Lavtar, Polona, et al. "Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis." PLoS ONE, vol. 13, no. 1, 2018, pp. 1-7. https://doi.org/10.1371/journal.pone.0190601

Lavtar, Polona, Gorazd Rudolf, Ales Maver, Alenka Hodžić, Nada Starčević Čizmarević, Maja Živkovic, Sasa Sega Jazbec, et al. "Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis." PLoS ONE 13, no. 1 (2018): 1-7. https://doi.org/10.1371/journal.pone.0190601

Lavtar, P., et al. (2018) 'Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis', PLoS ONE, 13(1), pp. 1-7. doi: 10.1371/journal.pone.0190601

Lavtar P, Rudolf G, Maver A, Hodžić A, Čizmarević NS, Živkovic M, and sur.. Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis. PLoS ONE [Internet]. 2018 January 18 [cited 2024 April 27];13(1):1-7. doi: 10.1371/journal.pone.0190601

P. Lavtar, et al., "Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis", PLoS ONE, vol. 13, no. 1, pp. 1-7, January 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:136979. [Accessed: 27 April 2024]

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Metadata
Title (english)Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
AuthorPolona Lavtar
AuthorGorazd Rudolf
AuthorAles Maver
AuthorAlenka Hodžić
AuthorNada Starčević Čizmarević
AuthorMaja Živkovic
AuthorSasa Sega Jazbec
AuthorZalika Klemenc Ketis
AuthorMiljenko Kapović
AuthorEvica Dinčić
AuthorRanko Raičević
AuthorJuraj Sepčić
AuthorLuca Lovrečić
AuthorAleksandra Stanković
AuthorSmiljana Ristić
MBZ: 142283
AuthorBorut Peterlin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ARNTL and CLOCK, and their association with multiple sclerosis. A total of 900 Caucasian patients and 1024 healthy controls were compared for genetic signature at 8 SNPs, 4 for each of both genes. We found a statistically significant difference in genotype (ARNTL rs3789327, P = 7.5.10(-5); CLOCK rs6811520 P = 0.02) distributions in patients and controls. The ARNTL rs3789327 CC genotype was associated with higher risk for multiple sclerosis at an OR of 1.67 (95% CI 1.35-2.07, P = 0.0001) and the CLOCK rs6811520 genotype CC at an OR of 1.40 (95% CI 1.13-1.73, P = 0.002). The results of this study suggest that genetic variability in the ARNTL and CLOCK genes might be associated with risk for multiple sclerosis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePLoS ONE
Numberingvol. 13, no. 1, pp. 1-7
e-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0190601
URN:NBNurn:nbn:hr:184:136979
Publication2018-01-18
Document URLhttps://doi.org/10.1371/journal.pone.0190601
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-02-27 12:58:12