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Professional paper - Review paper
PATOGENEZA PSORIJATIČNOG ARTRITISA
Reumatizam, 64 (2017), suppl. 1; 17-21. urn:nbn:hr:184:830795
Novak, Srđan; Zekić, Tatjana

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Novak, S. & Zekić, T. (2017). PATOGENEZA PSORIJATIČNOG ARTRITISA. Reumatizam, 64. (suppl. 1), 17-21. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:830795

Novak, Srđan and Tatjana Zekić. "PATOGENEZA PSORIJATIČNOG ARTRITISA." Reumatizam, vol. 64, no. suppl. 1, 2017, pp. 17-21. https://urn.nsk.hr/urn:nbn:hr:184:830795

Novak, Srđan and Tatjana Zekić. "PATOGENEZA PSORIJATIČNOG ARTRITISA." Reumatizam 64, no. suppl. 1 (2017): 17-21. https://urn.nsk.hr/urn:nbn:hr:184:830795

Novak, S. and Zekić, T. (2017) 'PATOGENEZA PSORIJATIČNOG ARTRITISA', Reumatizam, 64(suppl. 1), pp. 17-21. Available at: https://urn.nsk.hr/urn:nbn:hr:184:830795 (Accessed 30 September 2024)

Novak S, Zekić T. PATOGENEZA PSORIJATIČNOG ARTRITISA. Reumatizam [Internet]. 2017 October 25 [cited 2024 September 30];64(suppl. 1):17-21. Available at: https://urn.nsk.hr/urn:nbn:hr:184:830795

S. Novak and T. Zekić, "PATOGENEZA PSORIJATIČNOG ARTRITISA", Reumatizam, vol. 64, no. suppl. 1, pp. 17-21, October 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:830795. [Accessed: 30 September 2024]

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Metadata
Title (croatian)PATOGENEZA PSORIJATIČNOG ARTRITISA
Title (english)PATHOGENESIS OF PSORIATIC ARTHRITIS
AuthorSrđan Novak
AuthorTatjana Zekić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (croatian)
Nastanak psorijatičnog artritisa povezuje se s genetskim i imunosnim čimbenicima te čimbenicima okoliša. Psorijaza i psorijatični artritis povezani su s alelima MHC-a razreda I; psorijaza s HLA-C*06, a psorijatični artritis s HLA-B*08, B*27, B*38 i B*39. Prirođena i stečena imunost pridonose patogenezi psorijatičnog artritisa. Ključni citokini u patogenezi psorijatičnog artritisa jesu IL-12/23, IL-17A i TNF-α zbog čega je dosadašnje liječenje usmjereno prema njihovoj blokadi. Erozije kosti posredovane su signalnim putovima NF-κB, IL-17 i RANKL. Recentne studije naglašavaju biomehaničko naprezanje tetiva i mikrotraumu kao inicijalne faktore upale. Supklinička upala crijeva i disbioza crijevnog mikrobioma također su mogući pokretači bolesti. Dosadašnje spoznaje o ključnim molekulama u patogenezi psorijatičnog artritisa otvaraju putove novim istraživanjima i mogućnostima liječenja.
Abstract (english)
Th e occurrence of psoriatic arthritis is associated with genetic, immune, and environmental factors. Psoriasis and psoriatic arthritis are associated with MHC class I gene alleles; psoriasis with HLA-C*06, and psoriatic arthritis with HLA-B*08, B*27, B*38, and B*39. Both innate and adaptive immunity contribute to the pathogenesis of psoriatic arthritis. Key cytokines in the pathogenesis of psoriatic arthritis are IL 12/23, IL 17A, and TNFα, which is why current treatment aims at blocking them. Bone erosions are mediated by NF-κB, IL-17, and RANKL signaling pathways. Recent studies emphasize biomechanical stress on tendons and microtrauma as initial factors of infl ammation. Subclinical gut infl ammation and microbial dysbiosis are possible triggers of disease, too. Recently acquired knowledge about key molecules in the pathogenesis of psoriatic arthritis will lead to new investigations and treatment opportunities.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleReumatizam
Numberingvol. 64, no. suppl. 1, pp. 17-21
p-ISSN0374-1338
URN:NBNurn:nbn:hr:184:830795
Publication2017-10-25
Document URLhttp://hrcak.srce.hr/188331
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-11-02 18:13:44