prikaz prve stranice dokumenta The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion
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Scientific paper - Original scientific paper
The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion
Journal of Assisted Reproduction and Genetics, 32 (2015), 12; 1789-1794. https://doi.org/10.1007/s10815-015-0593-0
Pereza, Nina; Ostojić, Saša; Smirčić, Anamarija; Hodžić, Alenka; Kapović, Miljenko; Peterlin, Borut

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Pereza, N., Ostojić, S., Smirčić, A., Hodžić, A., Kapović, M. & Peterlin, B. (2015). The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion. Journal of Assisted Reproduction and Genetics, 32. (12), 1789-1794. doi: 10.1007/s10815-015-0593-0

Pereza, Nina, et al. "The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion." Journal of Assisted Reproduction and Genetics, vol. 32, no. 12, 2015, pp. 1789-1794. https://doi.org/10.1007/s10815-015-0593-0

Pereza, Nina, Saša Ostojić, Anamarija Smirčić, Alenka Hodžić, Miljenko Kapović and Borut Peterlin. "The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion." Journal of Assisted Reproduction and Genetics 32, no. 12 (2015): 1789-1794. https://doi.org/10.1007/s10815-015-0593-0

Pereza, N., et al. (2015) 'The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion', Journal of Assisted Reproduction and Genetics, 32(12), pp. 1789-1794. doi: 10.1007/s10815-015-0593-0

Pereza N, Ostojić S, Smirčić A, Hodžić A, Kapović M, Peterlin B. The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion. Journal of Assisted Reproduction and Genetics [Internet]. 2015 [cited 2024 November 11];32(12):1789-1794. doi: 10.1007/s10815-015-0593-0

N. Pereza, S. Ostojić, A. Smirčić, A. Hodžić, M. Kapović and B. Peterlin, "The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion", Journal of Assisted Reproduction and Genetics, vol. 32, no. 12, pp. 1789-1794, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:897745. [Accessed: 11 November 2024]

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Metadata
Title (english)The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion
AuthorNina Pereza
AuthorSaša Ostojić
AuthorAnamarija Smirčić
AuthorAlenka Hodžić
AuthorMiljenko Kapović
AuthorBorut Peterlin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Purpose The vascular endothelial growth factor A (VEGFA) is crucial for normal vasculogenesis and angiogenesis during pregnancy, and alterations in the VEGFA gene expression were detected in women with idiopathic recurrent spontaneous abortion (IRSA) and spontaneously aborted conceptuses. Our aim was to evaluate whether there is an association between the functional −2549 insertion/deletion (I/D) polymorphism in the promoter region of the VEGFA gene and IRSA in reproductive couples. Methods We performed a case-control study involving 149 women and their 140 partners with three or more IRSA and 149 control women and men. Allele-specific polymerase chain reaction was used for genotyping. Results We found no association of the −2549 I/D polymorphism with IRSA in women. However, men with the DD genotype have a 1.75-fold increased risk of IRSA compared with men carrying the ID and II genotypes (95 % confidence interval (CI)=1.05–2.93, P=0.032). In addition, the D allele in men contributes to a 1.42-fold increased risk of IRSA (95 % CI= 1.02–1.97, P=0.036) compared to men carrying the I allele. Conclusions Our results indicate that the −2549 I/D polymorphism in the VEGFA gene in men might be associated with IRSA. Additional genetic association studies including both partners, as well as expression studies, are needed to elucidate the role of this polymorphism in IRSA.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Assisted Reproduction and Genetics
Numberingvol. 32, no. 12, pp. 1789-1794
p-ISSN1058-0468
e-ISSN1573-7330
DOIhttps://doi.org/10.1007/s10815-015-0593-0
URN:NBNurn:nbn:hr:184:897745
Publication2015
Document URLhttps://link.springer.com/content/pdf/10.1007%2Fs10815-015-0593-0.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-08-02 07:07:17