prikaz prve stranice dokumenta The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion
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The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion
Journal of Assisted Reproduction and Genetics, 32 (2015), 12; 1789-1794. https://doi.org/10.1007/s10815-015-0593-0
Pereza, Nina; Ostojić, Saša; Smirčić, Anamarija; Hodžić, Alenka; Kapović, Miljenko; Peterlin, Borut

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Pereza, N., Ostojić, S., Smirčić, A., Hodžić, A., Kapović, M. i Peterlin, B. (2015). The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion. Journal of Assisted Reproduction and Genetics, 32. (12), 1789-1794. doi: 10.1007/s10815-015-0593-0

Pereza, Nina, et al. "The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion." Journal of Assisted Reproduction and Genetics, vol. 32, br. 12, 2015, str. 1789-1794. https://doi.org/10.1007/s10815-015-0593-0

Pereza, Nina, Saša Ostojić, Anamarija Smirčić, Alenka Hodžić, Miljenko Kapović i Borut Peterlin. "The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion." Journal of Assisted Reproduction and Genetics 32, br. 12 (2015): 1789-1794. https://doi.org/10.1007/s10815-015-0593-0

Pereza, N., et al. (2015) 'The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion', Journal of Assisted Reproduction and Genetics, 32(12), str. 1789-1794. doi: 10.1007/s10815-015-0593-0

Pereza N, Ostojić S, Smirčić A, Hodžić A, Kapović M, Peterlin B. The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion. Journal of Assisted Reproduction and Genetics [Internet]. 2015. [pristupljeno 03.11.2024.];32(12):1789-1794. doi: 10.1007/s10815-015-0593-0

N. Pereza, S. Ostojić, A. Smirčić, A. Hodžić, M. Kapović i B. Peterlin, "The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion", Journal of Assisted Reproduction and Genetics, vol. 32, br. 12, str. 1789-1794, 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:897745. [Citirano: 03.11.2024.]

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Naslov (engleski)The −2549 insertion/deletion polymorphism in the promoter region of the VEGFA gene in couples with idiopathic recurrent spontaneous abortion
AutorNina Pereza
AutorSaša Ostojić
AutorAnamarija Smirčić
AutorAlenka Hodžić
AutorMiljenko Kapović
AutorBorut Peterlin
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Sažetak (engleski)
Purpose The vascular endothelial growth factor A (VEGFA) is crucial for normal vasculogenesis and angiogenesis during pregnancy, and alterations in the VEGFA gene expression were detected in women with idiopathic recurrent spontaneous abortion (IRSA) and spontaneously aborted conceptuses. Our aim was to evaluate whether there is an association between the functional −2549 insertion/deletion (I/D) polymorphism in the promoter region of the VEGFA gene and IRSA in reproductive couples. Methods We performed a case-control study involving 149 women and their 140 partners with three or more IRSA and 149 control women and men. Allele-specific polymerase chain reaction was used for genotyping. Results We found no association of the −2549 I/D polymorphism with IRSA in women. However, men with the DD genotype have a 1.75-fold increased risk of IRSA compared with men carrying the ID and II genotypes (95 % confidence interval (CI)=1.05–2.93, P=0.032). In addition, the D allele in men contributes to a 1.42-fold increased risk of IRSA (95 % CI= 1.02–1.97, P=0.036) compared to men carrying the I allele. Conclusions Our results indicate that the −2549 I/D polymorphism in the VEGFA gene in men might be associated with IRSA. Additional genetic association studies including both partners, as well as expression studies, are needed to elucidate the role of this polymorphism in IRSA.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Assisted Reproduction and Genetics
Brojčani podacivol. 32, br. 12, str. 1789-1794
p-ISSN1058-0468
e-ISSN1573-7330
DOIhttps://doi.org/10.1007/s10815-015-0593-0
URN:NBNurn:nbn:hr:184:897745
Datum objave publikacije2015
URL dokumentahttps://link.springer.com/content/pdf/10.1007%2Fs10815-015-0593-0.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2017-08-02 07:07:17