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Scientific paper - Original scientific paper
POLIMORFIZAM 4G/5G U PROMOTORSKOJ REGIJI GENA ZA INHIBITOR AKTIVATORA PLAZMINOGENA–1 KAO RIZIČNI ČIMBENIK U MULTIPLOJ SKLEROZI
Medicina, 42(40) (2004), 4; 271-275. urn:nbn:hr:184:630110
Ristić, Smiljana; Starčević-Čizmarević, Nada; Sepčić, Juraj; Rudež, Josip; Crnić-Martinović, Marija; Barac-Latas, Vesna; Kapović, Miljenko

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Ristić, S., Starčević Čizmarević, N., Sepčić, J., Rudež, J., Crnić Martinović, M., Barac Latas, V. & Kapović, M. (2004). POLIMORFIZAM 4G/5G U PROMOTORSKOJ REGIJI GENA ZA INHIBITOR AKTIVATORA PLAZMINOGENA–1 KAO RIZIČNI ČIMBENIK U MULTIPLOJ SKLEROZI. Medicina, 42(40). (4), 271-275. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:630110

Ristić, Smiljana, et al. "POLIMORFIZAM 4G/5G U PROMOTORSKOJ REGIJI GENA ZA INHIBITOR AKTIVATORA PLAZMINOGENA–1 KAO RIZIČNI ČIMBENIK U MULTIPLOJ SKLEROZI." Medicina, vol. 42(40), no. 4, 2004, pp. 271-275. https://urn.nsk.hr/urn:nbn:hr:184:630110

Ristić, Smiljana, Nada Starčević Čizmarević, Juraj Sepčić, Josip Rudež, Marija Crnić Martinović, Vesna Barac Latas and Miljenko Kapović. "POLIMORFIZAM 4G/5G U PROMOTORSKOJ REGIJI GENA ZA INHIBITOR AKTIVATORA PLAZMINOGENA–1 KAO RIZIČNI ČIMBENIK U MULTIPLOJ SKLEROZI." Medicina 42(40), no. 4 (2004): 271-275. https://urn.nsk.hr/urn:nbn:hr:184:630110

Ristić, S., et al. (2004) 'POLIMORFIZAM 4G/5G U PROMOTORSKOJ REGIJI GENA ZA INHIBITOR AKTIVATORA PLAZMINOGENA–1 KAO RIZIČNI ČIMBENIK U MULTIPLOJ SKLEROZI', Medicina, 42(40)(4), pp. 271-275. Available at: https://urn.nsk.hr/urn:nbn:hr:184:630110 (Accessed 26 December 2024)

Ristić S, Starčević Čizmarević N, Sepčić J, Rudež J, Crnić Martinović M, Barac Latas V, and sur.. POLIMORFIZAM 4G/5G U PROMOTORSKOJ REGIJI GENA ZA INHIBITOR AKTIVATORA PLAZMINOGENA–1 KAO RIZIČNI ČIMBENIK U MULTIPLOJ SKLEROZI. Medicina [Internet]. 2004 [cited 2024 December 26];42(40)(4):271-275. Available at: https://urn.nsk.hr/urn:nbn:hr:184:630110

S. Ristić, et al., "POLIMORFIZAM 4G/5G U PROMOTORSKOJ REGIJI GENA ZA INHIBITOR AKTIVATORA PLAZMINOGENA–1 KAO RIZIČNI ČIMBENIK U MULTIPLOJ SKLEROZI", Medicina, vol. 42(40), no. 4, pp. 271-275, 2004. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:630110. [Accessed: 26 December 2024]

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Title (croatian)POLIMORFIZAM 4G/5G U PROMOTORSKOJ REGIJI GENA ZA INHIBITOR AKTIVATORA PLAZMINOGENA–1 KAO RIZIČNI ČIMBENIK U MULTIPLOJ SKLEROZI
Title (english)4G/5G POLYMORPHISM IN PROMOTER REGION OF PLASMINOGEN ACTIVATOR INHIBITOR-1 GENE AS RISK FACTOR IN MULTIPLE SCLEROSIS
AuthorSmiljana Ristić
MBZ: 142283
AuthorNada Starčević-Čizmarević
AuthorJuraj Sepčić
AuthorJosip Rudež
AuthorMarija Crnić-Martinović
MBZ: 59531
AuthorVesna Barac-Latas
AuthorMiljenko Kapović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (croatian)
Da bi se ispitalo moguće značenje proteolitičkih mehanizama na razvoj upalnih lezija u MS-u, u radu je analiziran utjecaj polimorfizma 4G/5G u promotorskoj regiji gena za inhibitor aktivatora plazminogena- 1 (PAI-1) na podložnost za MS i kliničku ekspresiju bolesti. Ispitanici su bili bolesnici iz Gorkog kotara s klinički sigurnim i laboratorijski potvr|đenim sigurnim MS-om (N=46), a u kontrolnoj su skupini bili dobrovoljni davatelji krvi, autohtoni stanovnici iz istog područja (N=101). Rezultati su pokazali da se distribucija PAI-1 genotipova i alela u MS-bolesnika nije statistički razlikovala od učestalosti u zdravih ispitanika, a razlike nije bilo niti kada su uspore|đeni pojedini subtipovi bolesti (PP, SP i RR) međ|usobno kao i sa zdravim ispitanicima. Nije bilo ni statistički značajne razlike u dobi nastupa i progresiji bolesti izme|đu pojedinih PAI-1 genotipova. Stoga možemo zaključiti da polimorfizam 4G/5G PAI-1 gena nema utjecaja na podložnost kao ni na ekspresiju bolesti u MS-bolesnika iz Gorskog kotara
Abstract (english)
In view of the potential importance of the proteolytic mechanisms in the development of MS lesions, the authors studied whether the 4G/5G promoter polymorphism of the plasminogen activator inhibitor 1 (PAI 1) gene may play a role in the clinical characteristics of Gorski kotar MS patients and their potential genetic susceptibility to MS. A total of 46 patients with clinically definite and laboratory supported MS were recruited from Gorski kotar region, while the control group consisted of 101 unrelated ethnically matched healthy blood donors. The distribution of PAI-1 genotypes and alleles in MS patients was similar to the distribution pattern in healthy donors. Furthermore, no association was observed between the PAI-1 promoter polymorphism and clinical characteristics, such as clinical course, age of disease onset and disease progression. Therefore, we can conclude that the 4G/5G promoter polymorphism of the PAI-1 gene does not influence the susceptibility to MS or the clinical characteristics of MS in Gorski kotar patients.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina
Numberingvol. 42(40), no. 4, pp. 271-275
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:630110
Publication2004
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-06-09 13:47:43