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Professional paper - Review paper
Patohistološki pokazatelji i mitotski indeks kao prognostički faktori kod primarnih melanoma kože
Medicina Fluminensis, 48 (2012), 2; 164-172. urn:nbn:hr:184:178304
Budisavljević, Ivana; Babarović, Emina; Ljubačev, Aleksandra; Mustać, Elvira; Zamolo, Gordana

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Budisavljević, I., Babarović, E., Ljubačev, A., Mustać, E. & Zamolo, G. (2012). Patohistološki pokazatelji i mitotski indeks kao prognostički faktori kod primarnih melanoma kože. Medicina Fluminensis, 48. (2), 164-172. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:178304

Budisavljević, Ivana, et al. "Patohistološki pokazatelji i mitotski indeks kao prognostički faktori kod primarnih melanoma kože." Medicina Fluminensis, vol. 48, no. 2, 2012, pp. 164-172. https://urn.nsk.hr/urn:nbn:hr:184:178304

Budisavljević, Ivana, Emina Babarović, Aleksandra Ljubačev, Elvira Mustać and Gordana Zamolo. "Patohistološki pokazatelji i mitotski indeks kao prognostički faktori kod primarnih melanoma kože." Medicina Fluminensis 48, no. 2 (2012): 164-172. https://urn.nsk.hr/urn:nbn:hr:184:178304

Budisavljević, I., et al. (2012) 'Patohistološki pokazatelji i mitotski indeks kao prognostički faktori kod primarnih melanoma kože', Medicina Fluminensis, 48(2), pp. 164-172. Available at: https://urn.nsk.hr/urn:nbn:hr:184:178304 (Accessed 04 November 2024)

Budisavljević I, Babarović E, Ljubačev A, Mustać E, Zamolo G. Patohistološki pokazatelji i mitotski indeks kao prognostički faktori kod primarnih melanoma kože. Medicina Fluminensis [Internet]. 2012 June 04 [cited 2024 November 04];48(2):164-172. Available at: https://urn.nsk.hr/urn:nbn:hr:184:178304

I. Budisavljević, E. Babarović, A. Ljubačev, E. Mustać and G. Zamolo, "Patohistološki pokazatelji i mitotski indeks kao prognostički faktori kod primarnih melanoma kože", Medicina Fluminensis, vol. 48, no. 2, pp. 164-172, June 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:178304. [Accessed: 04 November 2024]

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Title (croatian)Patohistološki pokazatelji i mitotski indeks kao prognostički faktori kod primarnih melanoma kože
Title (english)Patohistological parameters and mitotic rate as a prognostic factor in primary melanoma of the skin
AuthorIvana Budisavljević
AuthorEmina Babarović
AuthorAleksandra Ljubačev
AuthorElvira Mustać
AuthorGordana Zamolo
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (croatian)
Maligni melanom kože nastaje malignom transformacijom melanocita. Karakterizira ga lokalna agresivnost i sklonost ranom limfogenom i hematogenom metastaziranju. Iako se nekoliko posljednjih godina bilježi bolje preživljenje, što je rezultat dijagnoze u ranoj fazi bolesti, i dalje se nastoje naći prognostički pokazatelji koji bi omogućili pouzdanije predviđanje tijeka bolesti uz modifikaciju terapije. Stoga je svrha ovog preglednog rada bila utvrditi koji patohistološki i klinički parametri imaju ulogu u prognozi bolesnika s malignim melanomom i mogu li nam ti pokazatelji pomoći u određivanju terapije kod bolesnika. Ovisno o histološkom tipu tumora, spol, histološka razina invazije, debljina tumora i mitotski indeks važni su za prognozu bolesnika s malignim melanomom kože, dok neovisno o histološkom tipu tumora u prognozi bolesnika ulogu ima histološka razina invazije kože, debljina tumora i mitotski indeks.
Abstract (english)
Malignant melanoma of the skin arises due to neoplastic transformation of melanocytes. Its behavior is characterized not so much by the local agressiveness of the primary tumor but rather by the pronounced and often very early tendency to produce lymphogenous and hematogenous metastases. In the last few years a better rate of survival has been observed as a result of early diagnosis. However, recent studies have been focused on determining reliable prognostic parameters which would allow more consistent and predictable course of disease with modification of therapy. The aim of this review was to determine the most important histopathological and clinical parameters which influence the prognosis and outcome of patients with malignant melanoma, and whether they can aid in the choice of the most suitable form of therapy. Depending of the histological type of tumor, patient gender, histological level of tumor progression according to Clark, tumor thickness according to Breslow and mitotic rate are considered to be the parameters of crucial importance for the prognosis of patients with malignant melanoma of the skin. The histological level of tumor progression according to Clark, tumor thickness according to Breslow and mitotic rate were proven to be independent, statistically significant parameters relevant for the outcome of patients with this disease.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis
Numberingvol. 48, no. 2, pp. 164-172
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:178304
Publication2012-06-04
Document URLhttp://hrcak.srce.hr/84190
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-11 15:36:53