prikaz prve stranice dokumenta Undifferentiated pleomorphic breast sarcoma in a male patient
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Scientific paper - Case study
Undifferentiated pleomorphic breast sarcoma in a male patient
Libri Oncologici : Croatian Journal of Oncology, 52 (2024), 2-3; 146-150. https://doi.org/10.20471/LO.2024.52.02-03.21
Grebić, Damir; Oštrić, Marin; Radoš, Laura; Radošević, Mia; Gospić, Marko

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Grebić, D., Oštrić, M., Radoš, L., Radošević, M. & Gospić, M. (2024). Undifferentiated pleomorphic breast sarcoma in a male patient. Libri Oncologici : Croatian Journal of Oncology, 52. (2-3), 146-150. doi: 10.20471/LO.2024.52.02-03.21

Grebić, Damir, et al. "Undifferentiated pleomorphic breast sarcoma in a male patient." Libri Oncologici : Croatian Journal of Oncology, vol. 52, no. 2-3, 2024, pp. 146-150. https://doi.org/10.20471/LO.2024.52.02-03.21

Grebić, Damir, Marin Oštrić, Laura Radoš, Mia Radošević and Marko Gospić. "Undifferentiated pleomorphic breast sarcoma in a male patient." Libri Oncologici : Croatian Journal of Oncology 52, no. 2-3 (2024): 146-150. https://doi.org/10.20471/LO.2024.52.02-03.21

Grebić, D., et al. (2024) 'Undifferentiated pleomorphic breast sarcoma in a male patient', Libri Oncologici : Croatian Journal of Oncology, 52(2-3), pp. 146-150. doi: 10.20471/LO.2024.52.02-03.21

Grebić D, Oštrić M, Radoš L, Radošević M, Gospić M. Undifferentiated pleomorphic breast sarcoma in a male patient. Libri Oncologici : Croatian Journal of Oncology [Internet]. 2024 [cited 2025 March 10];52(2-3):146-150. doi: 10.20471/LO.2024.52.02-03.21

D. Grebić, M. Oštrić, L. Radoš, M. Radošević and M. Gospić, "Undifferentiated pleomorphic breast sarcoma in a male patient", Libri Oncologici : Croatian Journal of Oncology, vol. 52, no. 2-3, pp. 146-150, 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:907103. [Accessed: 10 March 2025]

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Metadata
Title (english)Undifferentiated pleomorphic breast sarcoma in a male patient
Title (croatian)Nediferencirani pleomorfni sarkom dojke u muškarca
AuthorDamir Grebić
AuthorMarin Oštrić
AuthorLaura Radoš
AuthorMia Radošević
AuthorMarko Gospić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Objective: The objective of this case report is to present a rare case of inflammatory undifferentiated pleomorphic sarcoma in a male breast. Case report: a 64-year-old man palpated a painless nodule on the left breast. Core needle biopsy did not reveal the final diagnosis as it was classified as B3 so an excisional biopsy of the tissue was performed, which revealed an undifferentiated pleomorphic sarcoma with a diameter of 4.5 cm, infiltrated with inflammatory cells. After we confirmed the sarcoma operation therapy was indicated. Stewart incision was performed and mastectomy was done. Pathohistological analysis confirmed negative surgical resection margins. After one month PET CT scan revealed lungs metastases and the patient underwent 6 chemotherapy cycles of doxorubicin with good response and contribution of lungs metastases remission. Three years later, the tumor recurred and infiltrated the thoracic wall. The patient underwent again to surgical procedure. We did the extirpation of tumor, resection of thoracic wall with large pectoral muscle and within fifth, sixth and seventh ribs resection and thoracoplasty with core matrix and bio-net was performed for reconstruction of the defect. On pathohistology findings distal resection margin was infiltrated by tumor cells so radiotherapy was performed. Larger thoracic resection was not possible as it would affect breathing mechanics. The postoperative course was normal, without paradoxical breathing. The patient has been in remission according to PET-CT examination for four years after them treatment. Conclusion: We have presented a rare case of undifferentiated pleomorphic sarcoma in the breast, its potential for recurrence and distant metastases, the possibilities of treatment, the importance and limitations of operative treatment as well as benefit of oncological procedures and unpredictable clinical course of disease.
Abstract (croatian)
Cilj: Cilj je ovog rada prikazati rijedak slučaj inflamatornog nediferenciranog pleomorfnog sarkoma u muškoj dojci. Prikaz slučaja: 64-godišnji muškarac napipao je bezbolni čvor u lijevoj dojci. Širokoiglena biopsija nije razjasnila završnu dijagnozu te je klasificirana sa B3. Stoga se pristupilo operacijskom postupku. Učinjena je ekstirpacija tumora, a patohistološki nalaz potvrdio je nediferencirani pleomorfni sarkom promjera 4,5 cm, infiltriran upalnim stanicama. Nakon potvrde sarcoma indicirana je bila operacijska terapija. Pristupilo se inciziji po Stewartu te se učinila mastektomija. Patohistološkom analizom potvrđeni su negativni kirurški resekcijski rubovi. Mjesec dana kasnije PET CT pregledom otkrivene su plućne metastaze, zbog čega je pacijent prošao kroz 6 kemoterapijskih ciklusa doksorubicina sa dobrim odgovorom na terapiju te je postignuta kompletna remisija plućnih metastaza. Tri godine kasnije CT nalaz pokazao je recidiv tumora sa infiltracijom cijele debljine torakalne stijenke. Indicirano je bilo kirurško liječenje. Operacijom je uklonjen tumor i veliki pektoralni mišić u bloku sa šestim, sedmim i osmim rebrom te je učinjena torakoplastika core matrixom i biološkom mrežicom u svrhu rekonstrukcije defekta. U patohistološkom nalazu distalni resekcijski rub bio je pozitivan, infiltriran tumorskim stanicama, te je stoga bolesnik bio podvrgnut radioterapiji. Širi opseg operacije nije bio moguć zbog opasnosti utjecaja na mehaniku disanja. Postoperativni tijek je bio uredan, bez paradoksalnog disanja. Bolesnik je sljedeće četri godine praćen jednom godišnje PET CT- om te do sada nije imao znakove ponovnog recidiva bolesti kao niti metastaza. Zaključak: Prikazali smo rijedak slučaj nediferenciranog pleomorfnog sarkoma u dojci, njegov potencijal za lokalnu invaziju i sklonost recidiviranju kao i metastaziranju, te važnost, ali i ograničenja operativnog liječenja kao i značaj sveobuhvatne onkološke terapije i nepredvidiv klinički tijek bolesti.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLibri Oncologici : Croatian Journal of Oncology
Numberingvol. 52, no. 2-3, pp. 146-150
p-ISSN0300-8142
e-ISSN2584-3826
DOIhttps://doi.org/10.20471/LO.2024.52.02-03.21
URN:NBNurn:nbn:hr:184:907103
Publication2024
Document URLhttps://hrcak.srce.hr/328840
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2025-03-10 08:08:50