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Scientific paper - Case study
The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature
Case Reports in Oncology, 18 (2024), 1; 7-14. https://doi.org/10.1159/000541419
Bukovica Petrc, Anamarija; Salopek, Tihana; Skočilić, Iva; Zahirovic, Dag; Orlić, Lidija; Bubić, Ivan; Matana-Kaštelan, Zrinka; Francetić, Sara; Lisica, Karla; Mikolašević, Ivana

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Bukovica Petrc, A., Salopek, T., Skočilić, I., Zahirovic, D., Orlić, L., Bubić, I. ... Mikolašević, I. (2024). The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature. Case Reports in Oncology, 18. (1), 7-14. doi: 10.1159/000541419

Bukovica Petrc, Anamarija, et al. "The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature." Case Reports in Oncology, vol. 18, no. 1, 2024, pp. 7-14. https://doi.org/10.1159/000541419

Bukovica Petrc, Anamarija, Tihana Salopek, Iva Skočilić, Dag Zahirovic, Lidija Orlić, Ivan Bubić, Zrinka Matana Kaštelan, Sara Francetić, Karla Lisica and Ivana Mikolašević. "The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature." Case Reports in Oncology 18, no. 1 (2024): 7-14. https://doi.org/10.1159/000541419

Bukovica Petrc, A., et al. (2024) 'The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature', Case Reports in Oncology, 18(1), pp. 7-14. doi: 10.1159/000541419

Bukovica Petrc A, Salopek T, Skočilić I, Zahirovic D, Orlić L, Bubić I, and sur.. The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature. Case Reports in Oncology [Internet]. 2024 December 19 [cited 2025 March 05];18(1):7-14. doi: 10.1159/000541419

A. Bukovica Petrc, et al., "The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature", Case Reports in Oncology, vol. 18, no. 1, pp. 7-14, December 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:205295. [Accessed: 05 March 2025]

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Metadata
Title (english)The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature
AuthorAnamarija Bukovica Petrc
AuthorTihana Salopek
AuthorIva Skočilić
AuthorDag Zahirovic
AuthorLidija Orlić
AuthorIvan Bubić
AuthorZrinka Matana-Kaštelan
AuthorSara Francetić
AuthorKarla Lisica
AuthorIvana Mikolašević
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Introduction: Melanoma often metastasizes to the liver, leading to significant morbidity and mortality. Liver injury can also occur due to hepatitis caused by immunotherapy used in the treatment of melanoma. Case Presentation: This case report presents a 38-year-old male diagnosed with advanced melanoma who experienced acute liver failure (ALF) initially thought to be a side effect of immunotherapy. Despite following aggressive supportive care as per the latest guidelines, the patient’s condition deteriorated rapidly. It was discovered that the patient had liver metastases. As the tumor had a positive BRAF mutation, we opted for invasive treatment with therapeutic plasma exchange to restore liver function and create the conditions for initiating treatment with BRAF/MEK inhibitors. After the use of a liver support device, the liver function was resolved, and a BRAF/MEK inhibitor was introduced. After 2 months of targeted therapy, a favorable effect and good melanoma control are observed. Conclusion: The report underscores the complexity of managing melanoma with liver metastasis and the urgent need for advancements in treatment modalities ALF in oncology patients. We suggest that invasive treatment methods, such as liver support system devices, should be considered in well-selected oncology patients, even in advanced stages of disease.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCase Reports in Oncology
Numberingvol. 18, no. 1, pp. 7-14
e-ISSN1662-6575
DOIhttps://doi.org/10.1159/000541419
URN:NBNurn:nbn:hr:184:205295
Publication2024-12-19
Document URLhttps://karger.com/doi/10.1159/000541419
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2025-03-05 12:51:14