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Scientific paper - Review paper
Decoding the Epigenetics of Infertility: Mechanisms, Environmental Influences, and Therapeutic Strategies
Epigenomes, 8 (2024), 3; 34. https://doi.org/10.3390/epigenomes8030034
Saftić Martinović, Lara; Mladenić, Tea; Lovrić, Dora; Ostojić, Saša; Dević Pavlić, Sanja

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Saftić Martinović, L., Mladenić, T., Lovrić, D., Ostojić, S. & Dević Pavlić, S. (2024). Decoding the Epigenetics of Infertility: Mechanisms, Environmental Influences, and Therapeutic Strategies. Epigenomes, 8. (3). doi: 10.3390/epigenomes8030034

Saftić Martinović, Lara, et al. "Decoding the Epigenetics of Infertility: Mechanisms, Environmental Influences, and Therapeutic Strategies." Epigenomes, vol. 8, no. 3, 2024. https://doi.org/10.3390/epigenomes8030034

Saftić Martinović, Lara, Tea Mladenić, Dora Lovrić, Saša Ostojić and Sanja Dević Pavlić. "Decoding the Epigenetics of Infertility: Mechanisms, Environmental Influences, and Therapeutic Strategies." Epigenomes 8, no. 3 (2024). https://doi.org/10.3390/epigenomes8030034

Saftić Martinović, L., et al. (2024) 'Decoding the Epigenetics of Infertility: Mechanisms, Environmental Influences, and Therapeutic Strategies', Epigenomes, 8(3). doi: 10.3390/epigenomes8030034

Saftić Martinović L, Mladenić T, Lovrić D, Ostojić S, Dević Pavlić S. Decoding the Epigenetics of Infertility: Mechanisms, Environmental Influences, and Therapeutic Strategies. Epigenomes [Internet]. 2024 September 05 [cited 2024 December 18];8(3). doi: 10.3390/epigenomes8030034

L. Saftić Martinović, T. Mladenić, D. Lovrić, S. Ostojić and S. Dević Pavlić, "Decoding the Epigenetics of Infertility: Mechanisms, Environmental Influences, and Therapeutic Strategies", Epigenomes, vol. 8, no. 3, September 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:835586. [Accessed: 18 December 2024]

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Metadata
Title (english)Decoding the Epigenetics of Infertility: Mechanisms, Environmental Influences, and Therapeutic Strategies
AuthorLara Saftić Martinović
AuthorTea Mladenić
AuthorDora Lovrić
AuthorSaša Ostojić
AuthorSanja Dević Pavlić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
Infertility is a complex condition caused by a combination of genetic, environmental, and lifestyle factors. Recent advances in epigenetics have highlighted the importance of epigenetic changes in fertility regulation. This review aims to provide a comprehensive overview of the epigenetic mechanisms involved in infertility, with a focus on DNA methylation, histone modification, and non-coding RNAs. We investigate the specific epigenetic events that occur during gametogenesis, with a focus on spermatogenesis and oogenesis as distinct processes. Furthermore, we investigate how environmental factors such as diet, stress, and toxin exposure can influence these epigenetic changes, potentially leading to infertility. The second part of the review explores epigenetic changes as therapeutic targets for infertility. Emerging therapies that modulate epigenetic marks present promising opportunities for fertility restoration, particularly in spermatogenesis. By summarizing current research findings, this review emphasizes the importance of understanding epigenetic contributions to infertility. Our discussion aims to lay the groundwork for future research directions and clinical applications in reproductive health.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEpigenomes
Numberingvol. 8, no. 3, 34
e-ISSN2075-4655
DOIhttps://doi.org/10.3390/epigenomes8030034
URN:NBNurn:nbn:hr:184:835586
Publication2024-09-05
Document URLhttps://www.mdpi.com/2075-4655/8/3/34
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-09-13 10:51:22