Professional paper - Review paper
Plant lectins in cancer prevention and treatment

Giacometti, Jasminka (2015)
Metadata
Language English
Title (Croatian)Biljni lektini u prevenciji i liječenju raka
Title (English)Plant lectins in cancer prevention and treatment
AuthorGiacometti, Jasminka
Abstract (Croatian)
Biljni lektini su specifični glikoproteini koji su široko rasprostranjeni u različitim biljnim vrstama. Sudjeluju u mnogim fiziološkim procesima gdje moduliraju imunološki odgovor. Velik interes za ovu skupinu proteina javio se zbog njihove sposobnosti da utječu na protutumorsku aktivnost putem stanične adhezije, stanične proliferacije i indukcije apoptoze. No još su uvijek nerazjašnjena neka pitanja koja se odnose na molekularni mehanizam / metaboličke puteve i biološke učinke lektina. Novi izazovi u istraživanju lektina odnose se na njihovu primjenu u nanotehnologiji te razvoju glikoproteomike. Glikoproteomika je jedan od moćnih alata u karakterizaciji lektina, a u bliskoj budućnosti i neizostavni alat u razvoju lijekova koji se temelje na lektinima. Ovaj pregledni rad ukratko upisuje izvore, strukturu i primjenu biljnih lektina, povezujući njihove složene mehanizme djelovanja u apoptozi i autofagiji. Opisana je primjena lektina u terapiji raka.
Abstract (English)
Plant lectins are specific carbohydrate-binding proteins that are widely distributed in various plant species. They participate in many physiological processes and are capable of modulating the immune response. Recently, greater attention has been drawn to their remarkable anticancer properties. Lectins are associated with cell adhesion, cell proliferation and induction of apoptosis. However, some of the questions related to the molecular mechanism / metabolic pathways and biological effects of lectins are still open. New challenges in the research of lectins are related to their application in nanotechnology and development of glycoproteomics. In addition, glycoproteomics is a powerful tool in the characterization of lectins and will be indispensable for development of lectin based drugs in the near future. This review provides a brief outline of the up-to-date advances in the field of plant lectins, focusing on their complex mechanisms implicated in apoptosis and autophagy. The current applications in cancer treatment are also described.
Keywords (Croatian)biljni lektini lektini protutumorski spojevi
Keywords (English)anticancer agents lectins plant lectins
Publication typeprofessional paper - review paper
Publication statuspublished
Peer reviewpeer review
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numbering2015, Vol. 51, No. 2, pp 211-229
ISSN0025-7729
Datepublication: 01.06.2015.
Article URLhttp://hrcak.srce.hr/139439
Scientific fieldBIOTECHNICAL SCIENCES
Biotechnology
InstitutionUniversity of Rijeka
(Department of Biotechnology)
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:052288