prikaz prve stranice dokumenta Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis
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Scientific paper - Original scientific paper
Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis
Osteoarthritis and Cartilage, 21 (2013), 11; 1724-1730. https://doi.org/10.1016/j.joca.2013.06.030
Bobinac, Dragica; Marinović, Marin; Bazdulj, E.; Cvijanović, Olga; Ćelic, T.anja; Marić, Ivana; Španjol, Josip; Cicvarić, Tedi

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Bobinac, D., Marinović, M., Bazdulj, E., Cvijanović, O., Ćelic, T., Marić, I. ... Cicvarić, T. (2013). Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis. Osteoarthritis and Cartilage, 21. (11), 1724-1730. doi: 10.1016/j.joca.2013.06.030

Bobinac, Dragica, et al. "Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis." Osteoarthritis and Cartilage, vol. 21, no. 11, 2013, pp. 1724-1730. https://doi.org/10.1016/j.joca.2013.06.030

Bobinac, Dragica, Marin Marinović, E. Bazdulj, Olga Cvijanović, T.anja Ćelic, Ivana Marić, Josip Španjol and Tedi Cicvarić. "Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis." Osteoarthritis and Cartilage 21, no. 11 (2013): 1724-1730. https://doi.org/10.1016/j.joca.2013.06.030

Bobinac, D., et al. (2013) 'Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis', Osteoarthritis and Cartilage, 21(11), pp. 1724-1730. doi: 10.1016/j.joca.2013.06.030

Bobinac D, Marinović M, Bazdulj E, Cvijanović O, Ćelic T, Marić I, and sur.. Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis. Osteoarthritis and Cartilage [Internet]. 2013 November [cited 2024 May 05];21(11):1724-1730. doi: 10.1016/j.joca.2013.06.030

D. Bobinac, et al., "Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis", Osteoarthritis and Cartilage, vol. 21, no. 11, pp. 1724-1730, November 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:528728. [Accessed: 05 May 2024]

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Metadata
Title (english)Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis
AuthorDragica Bobinac
AuthorMarin Marinović
AuthorE. Bazdulj
AuthorOlga Cvijanović
AuthorT.anja Ćelic
AuthorIvana Marić
AuthorJosip Španjol
AuthorTedi Cicvarić
Author's institution(Clinical Hospital Center Rijeka)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Objective: Explore whether osteoporosis (OP) in humans influences the morphological status of the articular cartilage and the subchondral bone. Explore the relationship between the macroscopic aspect of the articular surface and the rate of microscopic changes of both the cartilage and the subchondral bone in OP and osteoarthritis (OA). Methods: Femoral heads after total hip replacement were obtained from patients with OP or hip OA (OP, n=56; OA, n=12). Cartilage degeneration was assessed using the Mankin grading system whereas subchondral bone was evaluated using histomorphometry and Micro-computed Tomography (μCT) scanning system. Thickness of the cartilage layers and subchondral cortical bone (SCB) was measured. Results: Samples with higher total Mankin score have significantly reduced cartilage thickness. Mankin score differed between all OP specimens. In OP samples with lower Mankin scores the thickness of SCBshows a trend of an increase caused by increased levels of bone remodeling. In OP samples with higher Mankin scores we observed thinning of SCB. Structural indices of subchondral trabecular bone (STB) were significantly lower in OP than in OA samples. Conclusion: Thinning of SCB, found in OP samples with higher Mankin scores could be related with the progression of the cartilage degeneration indicating an early-stage OA. Increased levels of bone remodeling and evidently changed morphology of subchondral bone found in OP samples with lower Mankin score indicated that bony bed level must have a role in the progression of the cartilage degeneration.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleOsteoarthritis and Cartilage
Numberingvol. 21, no. 11, pp. 1724-1730
p-ISSN1063-4584
DOIhttps://doi.org/10.1016/j.joca.2013.06.030
URN:NBNurn:nbn:hr:184:528728
Publication2013-11
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S1063458413008662
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-11-11 07:54:47